BackgroundAdverse childhood experiences have been described as one of the major
environmental risk factors for depressive disorder. Similarly, the deleterious impact of early …

Kaufman et al.[2006] reported a higher order interaction effect between specific genetic and
environmental factors in a model of depressive symptoms, requiring independent …

Background: There is limited evidence for a moderating role of both serotonin transporter
(SERT) and brain-derived neurotrophic factor (BDNF) genes on the risk for major depression …

BACKGROUND: Child abuse and genotype interact to contribute to risk for depression in
children. This study examined gene-by-gene and gene-by-environment interactions …

Previous research examining gene–environment interaction (G× E) with regard to
vulnerability to depression and anxiety has yielded conflicting results. The present study was …

Both the serotonin transporter linked promoter region (5-HTTLPR) and the brain-derived
neurotrophic factor (BDNF) Val66Met polymorphisms have been shown to interact with …

Objective: Neurobiological and clinical studies suggest that childhood maltreatment may
result in functional and structural nervous system changes that predispose the individual to …

BACKGROUND: Based on biological interactions between the serotonergic system and the
brain-derived neurotrophic factor (BDNF), BDNF is a plausible candidate for a gene–gene …

Background Major depression is a disabling psychiatric illness with complex origins. Life
stress (childhood adversity and recent stressful events) is a robust risk factor for depression …

There is a strong etiological link between brain‐derived neurotrophic factor and depression,
but the neurocellular mechanisms and gene–environment interactions remain obscure. This …