[PDF][PDF] Prior knowledge and sampling model informed learning with single cell rna-seq data

S Mukherjee, Y Zhang, S Kannan, G Seelig - bioRxiv, 2017 - academia.edu
Single cell RNA-seq (scRNA-seq) experiments can provide a wealth of information about
heterogeneous, multi-cellular systems. However, this information has to be inferred …

Scalable preprocessing for sparse scRNA-seq data exploiting prior knowledge

S Mukherjee, Y Zhang, J Fan, G Seelig… - …, 2018 - academic.oup.com
Motivation Single cell RNA-seq (scRNA-seq) data contains a wealth of information which
has to be inferred computationally from the observed sequencing reads. As the ability to …

scRNA-seq mixology: towards better benchmarking of single cell RNA-seq analysis methods

L Tian, X Dong, S Freytag, KA Le Cao, S Su… - BioRxiv, 2018 - biorxiv.org
Single cell RNA sequencing (scRNA-seq) technology has undergone rapid development in
recent years, bringing with it new challenges in data processing and analysis. This has led …

Non-negative Independent Factor Analysis for single cell RNA-seq

W Mao, M Baran Pouyan, D Kostka, M Chikina - bioRxiv, 2020 - biorxiv.org
Motivation Single cell RNA sequencing (scRNA-seq) enables transcriptional profiling at the
level of individual cells. With the emergence of high-throughput platforms datasets …

Using Neural Networks to Improve Single Cell RNA-Seq Data Analysis

C Lin, S Jain, H Kim, Z Bar-Joseph - bioRxiv, 2017 - biorxiv.org
While only recently developed, the ability to profile expression data in single cells (scRNA-
Seq) has already led to several important studies and findings. However, this technology …

One Cell At a Time: A Unified Framework to Integrate and Analyze Single-cell RNA-seq Data

CX Wang, L Zhang, B Wang - bioRxiv, 2021 - biorxiv.org
The surge of single-cell RNA sequencing technologies gives rise to the abundance of large
single-cell RNA-seq datasets at the scale of hundreds of thousands of single cells …

One Cell At a Time (OCAT): a unified framework to integrate and analyze single-cell RNA-seq data

CX Wang, L Zhang, B Wang - Genome biology, 2022 - Springer
Integrative analysis of large-scale single-cell RNA sequencing (scRNA-seq) datasets can
aggregate complementary biological information from different datasets. However, most …

Monet: An open-source Python package for analyzing and integrating scRNA-Seq data using PCA-based latent spaces

F Wagner - bioRxiv, 2020 - biorxiv.org
Single-cell RNA-Seq is a powerful technology that enables the transcriptomic profiling of the
different cell populations that make up complex tissues. However, the noisy and high …

Information-theory-based benchmarking and feature selection algorithm improve cell type annotation and reproducibility of single cell RNA-seq data analysis …

Z Ren, M Gerlach, H Shi, AV Misharin, GRS Budinger… - bioRxiv, 2020 - biorxiv.org
Single cell RNA sequencing (scRNA-seq), which promises to enable the quantitative study
of biological processes at the single cell level, are now a routine part of experimental …

UNCURL-App: Interactive database-driven analysis of scRNA-Seq data

Y Zhang, S Mao, S Mukherjee, S Kannan, G Seelig - bioRxiv, 2020 - biorxiv.org
Motivation Analysis of single cell RNA sequencing (scRNA-seq) datasets is a complex and
time-consuming process, requiring both biological knowledge and technical skill. With the …