Early mammalian embryonic transcriptomes are dynamic throughout the process of
preimplantation development. Cataloging of primate transcriptomics during early …

The preimplantation period of life in mammals encompasses a tremendous amount of
restructuring and remodeling of the embryonic genome and reprogramming of gene …

Successful human development is dependent upon a cascade of events following
fertilization. Unfortunately, knowledge of these critical events in humans is remarkably …

The mouse embryo is the canonical model for mammalian preimplantation development.
Recent advances in single cell profiling allow detailed analysis of embryogenesis in other …

Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

The study of oocyte and preimplantation embryo biology has been regarded with great
curiosity throughout scientific history, but it is not until the development of robust methods for …

Early development in humans is characterised by low and variable embryonic viability,
reflected in low fecundity and high rates of miscarriage, relative to other mammals. Data from …

Differential gene expression is a prerequisite for the formation of multiple cell types from the
fertilized egg during embryogenesis. Understanding the gene regulatory networks …

In mammals, the development of pluripotency and specification of primordial germ cells
(PGCs) have been studied predominantly using mice as a model organism. However …

Detailed molecular studies of preimplantation stage development in a suitable nonhuman
primate model organism have been inhibited due to the cost and scarcity of embryos. To …