Hepcidin is a liver-derived hormone with a key role in iron homeostasis. In addition to iron, it
is regulated by inflammation and hypoxia, although mechanisms of hypoxic regulation …

The type II transmembrane serine protease matriptase-2 (TMPRSS6) down-regulates the
expression of hepcidin, the main regulator of systemic iron homeostasis, and increases in …

Iron overload disorders are characterized by the body's inability to regulate iron absorption
and its storage which can lead to organ failures. Accumulated evidence has revealed that …

The liver peptide hepcidin regulates body iron, is upregulated in iron overload and
inflammation, and is downregulated in iron deficiency/hypoxia. The transmembrane serine …

Hepcidin, the systemic regulator of iron homeostasis is activated by proteins responsible for
hereditary hemochromatosis, bone morphogenetic proteins (BMPs), and inflammatory …

Background Iron metabolism, regulated by the iron hormone hepcidin, and oxygen
homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected. We …

Hepcidin, a liver-derived protein that restricts enteric iron absorption, is the key regulator of
body iron content. Several proteins induce expression of the hepcidin-encoding gene Hamp …

Iron is essential for many biological processes, including oxygen delivery, and its supply is
tightly regulated. Hepcidin, a small peptide synthesized in the liver, is a key regulator of iron …

Hepcidin, a liver peptide, systemically inhibits iron utilization and is downregulated under
hypoxic conditions. However, little is known about the mechanism underlying the hypoxic …

Iron is essential for many biological processes, including oxygen delivery, and its supply is
tightly regulated. Hepcidin, a small peptide synthesized in the liver, is a key regulator of iron …