Pancreatic stellate cells are stromal cells that have multiple physiological functions such as
the production of extracellular matrix, stimulation of amylase secretion, phagocytosis and …

Pancreatic cancer is a strongly malignant gastrointestinal carcinoma characterized by late
detection, high mortality rates, poor patient prognosis and lack of effective treatments …

Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not
improved in decades. Treatments that target tumor cells have largely failed. This could be …

Pancreatic cancer is one of the most challenging adenocarcinomas due to its hostile
molecular behavior and complex tumor microenvironment. It has been recently postulated …

Tumour-stromal interactions have now been acknowledged to play a major role in
pancreatic cancer (PC) progression. The abundant collagenous stroma is produced by a …

Pancreatic stellate cells (PSCs) are responsible for producing the collagenous stroma in
pancreatic cancer. Findings from the majority of in vitro and in vivo studies to date indicate …

Since conventional and targeted therapies aiming at cancer cells have largely failed to
prolong survival in pancreatic cancer, targeting the infrastructure of the tumor, hence its …

Pancreatic cancer is characterized by its late detection, aggressive growth, intense
infiltration into adjacent tissue, early metastasis, resistance to chemo-and radiotherapy and …

There is accumulating evidence that activated pancreatic stellate cells (PSCs) play a pivotal
role in the development of pancreatic fibrosis within the pancreatic cancer tissue. Not only …

Pancreatic ductal adenocarcinoma is a devastating disease characterized by a dense
desmoplastic stroma. Chemo-and radio-therapeutic strategies based on targeting cancer …