Since its initial characterization, pancreatic ductal adenocarcinoma has remained one of the
most devastating and difficult cancers to treat. Pancreatic cancer is the fourth leading cause …

Pancreatic cancer is characterized by an extensive desmoplastic stroma, the functional
relevance of which is poorly understood. Activated fibroblasts are a prevalent component of …

Pancreatic stellate cells (PSCs) and cancer-associated fibroblasts (CAFs) are highly
abundant cells in the pancreatic tumor microenvironment (TME) that modulate desmoplasia …

Pancreatic stellate cells (PSCs) enhance the malignant behavior of pancreatic cancer by
interacting with cancer cells and producing extracellular matrix (ECM). To date, several …

As tumor microenvironments share many of the same qualities as chronic wounds, attention
is turning to the wound-repair cells that support the growth of cancerous cells. Stellate cells …

Chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC) are characterized by
extensive fibrosis. Importantly, in PDAC, this results in poor vascularization and impaired …

Activated pancreatic stellate cells (PSCs) play a central role in the tumor stroma of
pancreatic ductal adenocarcinoma (PDAC). Given the limited availability of patient-derived …

Pancreatic stellate cells play a pivotal role in the development of pancreatic fibrosis. A wide
variety of external stimuli can cause PSC activation accompanied by metabolic changes …

Pancreatic adenocarcinoma is characterized by a dense background of tumor associated
stroma originating from abundant pancreatic stellate cells. The aim of this study was to …

Abstract Purpose of Review The 5-year survival rate of patients with pancreatic cancer
(PanCA) has remained stagnant. Unfortunately, the incidence is almost equal to mortality …