Acetylcholinesterase (AChE) is responsible for hydrolysis of acetylcholine (ACh), a function,
which if disrupted, leads to cholinergic syndrome. Carbamates (CB) and organophosphorus …

Oxime K074 was formerly considered to be a lead structure for design of novel oximes for
reactivation of tabun-inhibited acetylcholinesterase (AChE). In this study, we are …

Oximes have been used as reactivators for organophosphorus-inhibited
acetylcholinesterase (AChE). However, it is still not clear why oximes are more efficient than …

The misuse of novichok agents in assassination attempts has been reported in the
international media since 2018. These relatively new class of neurotoxic agents is claimed …

The nerve agents of the A-series are relatively recent chemical weapons with no antidote
available yet. Once inside the human body, those chemicals act similarly to the classic nerve …

It is known that nerve agents are potent inhibitors of acetylcholinesterase (AChE), the
enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine and, thus …

The deleterious effects of nerve agents over the enzymes acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE) turned these compounds into the most dangerous chemical …

We have applied a theoretical methodology, previously developed to evaluate the
association and kinetic reactivation constants of oximes, comparing theoretical data …

The elucidation of the reactivation routes of human acetylcholinesterase (HuAChE) inhibited
by organophosphorous compounds is of crucial importance to the development of efficient …

Antidotes currently used for organophosphorus pesticide and nerve agent intoxications
consist of anticholinergics (atropine mainly) and acetylcholinesterase (AChE, EC 3.1. 1.7) …