New evidence for the effect of type 2 diabetes and glycemic traits on testosterone levels: a two-sample Mendelian randomization study

C Jiang, Y Wang, W Yang, X Yang - Frontiers in Endocrinology, 2023 - frontiersin.org
Objective Type 2 diabetes mellitus (T2DM) is an endocrine-related disease with an
increasing incidence worldwide. Male sexual dysfunction is common in diabetic patients …

Testosterone level and risk of type 2 diabetes in men: a systematic review and meta-analysis

Q Yao, B Wang, X An, J Zhang… - Endocrine …, 2018 - ec.bioscientifica.com
Background Type 2 diabetes is a risk factor for testosterone deficiency and impaired sex
steroid status. Some studies also investigated the association of testosterone level with …

[HTML][HTML] Sex-specific associations of testosterone with metabolic traits

SZ Lutz, R Wagner, L Fritsche, A Peter… - Frontiers in …, 2019 - frontiersin.org
Background: Testosterone levels are differentially linked with diabetes risk in men and
women: lower testosterone levels in men and higher testosterone levels in women are …

Testosterone levels and type 2 diabetes—no correlation with age, differential predictive value in men and women

M Karakas, S Schäfer, S Appelbaum, F Ojeda… - Biomolecules, 2018 - mdpi.com
Most studies reporting on the association of circulating testosterone levels with type 2
diabetes in men are of cross-sectional design. Reports on the relevance of altered …

Prediabetes is associated with an increased risk of testosterone deficiency, independent of obesity and metabolic syndrome

CH Ho, HJ Yu, CY Wang, FS Jaw, JT Hsieh, WC Liao… - PloS one, 2013 - journals.plos.org
Objective The association between type 2 diabetes and low testosterone has been well
recognized. However, testosterone levels in men with prediabetes have been rarely …

[HTML][HTML] Association between testosterone with type 2 diabetes in adult males, a meta-analysis and trial sequential analysis

J Zhang, X Li, Z Cai, H Li, B Yang - The Aging Male, 2019 - Taylor & Francis
Objective We performed this meta-analysis to assess serum testosterone changes in adult
males with Type 2 diabetes (T2DM). Methods PubMed, Embase, Web of Science, and …

The genetics of testosterone contributes to “femaleness/maleness” of cardiometabolic traits and type 2 diabetes

DE Vosberg, N Parker, J Shin, Z Pausova… - International Journal of …, 2022 - nature.com
The genetic architecture of testosterone is highly distinct between sexes. Moreover, obesity
is associated with higher testosterone in females but lower testosterone in males. Here, we …

Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis

EL Ding, Y Song, VS Malik, S Liu - Jama, 2006 - jamanetwork.com
ContextInconsistent data suggest that endogenous sex hormones may have a role in sex-
dependent etiologies of type 2 diabetes, such that hyperandrogenism may increase risk in …

Serum testosterone, sex hormone‐binding globulin and sex‐specific risk of incident type 2 diabetes in a retrospective primary care cohort

MW O'Reilly, M Glisic, B Kumarendran… - Clinical …, 2019 - Wiley Online Library
Objective Previous studies suggest that androgens have a sexually dimorphic impact on
metabolic dysfunction. However, the sex‐specific link between circulating androgens and …

Examining the associations between testosterone and biomarkers as men age

SJ Smith, D Bekele, AL Lopresti… - American Journal of …, 2023 - Wiley Online Library
Objectives Testosterone concentrations in men decline with advancing age. However, the
cause of the decline is yet to be fully elucidated. Therefore, the aims of this study were to …