Cytokines as Therapeutic Targets: Advances and Limitations: Immunity Skip to Main Content
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Influenza virus is a significant pathogen in humans and animals with the ability to cause
extensive morbidity and mortality. Exuberant immune responses induced following infection …

Inflammation is an essential immune response that enables survival during infection or
injury and maintains tissue homeostasis under a variety of noxious conditions. Inflammation …

Abstract Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological
functions and pathological significances and play an important role in health and disease. In …

Proinflammatory cytokines are potent mediators of numerous biological processes and are
tightly regulated in the body. Chronic uncontrolled levels of such cytokines can initiate and …

Macrophages, within the cytokine network, are a major source of many cytokines involved in
immune response, hematopoiesis, inflammation and many other homeostatic processes …

Sepsis and non-infectious systemic inflammatory response syndrome (SIRS) are
paradoxically associated with an exacerbated production of cytokines, as assessed by their …

Cytokines are a group of hormone-like polypeptide mediators that play a variety of
regulatory roles in both host defense and normal and abnormal homeostatic mechanisms …

Cytokines represent a multi-diverse family of polypeptide regulators; they are of relatively
low molecular weight, pharmacologically active proteins that are secreted by one cell for the …

Biochemically, interleukin-6 belongs to the class of four-helical cytokines. The cytokine can
be synthesised and secreted by many cells. It acts via a cell surface-expressed interleukin-6 …