Type III interferons (IFNs; IFN-λ) are antiviral cytokines with type I IFN-like biological
functions, including antiviral activity. In this article we review the literature on IFN-λ …

Highlights•IFNλs are dual function cytokines mediating antiviral activity and damage
control.•IFNλs confer initial antimicrobial protection at anatomical barriers without provoking …

Type-III interferons (IFN-λ, IFNL) are the most recently described family of IFNs. This family of
innate cytokines are increasingly being ascribed pivotal roles in host–pathogen interactions …

Type III interferons (IFNs)(or IFN-λ) are the latest addition to the IFN family. Even though they
share little protein homology with type I IFN, both exhibit remarkable functional similarities …

Human interferon lambdas (IFN-λ s)(type III IFNs) exhibit antiviral activity in vitro by binding
to a receptor complex distinct from that used by type I and type II IFNs, and subsequent …

ABSTRACT Interferon lambda 4 (IFN-λ4) is a recently identified enigmatic member of the
interferon (IFN) lambda family. Genetic data suggest that the IFNL4 gene acts in a proviral …

Neutrophils are increasingly appreciated as multifaceted regulators of innate immunity and
inflammation. Historically, these important innate cells have been considered suicidal …

For decades, type I IFNs have been considered indispensable and unique antiviral
mediators for the activation of rapid innate antiviral protection. However, the recent discovery …

Type I IFNs are well known players in immunity and autoimmunity. They induce potent
innate and adaptive immune responses essential for mediating host defenses against viral …

The interferon lambda family (IFN-λ1/2/3) is a newly described group of cytokines that are
related to both the type-1 interferons and IL-10 family members. These novel cytokines are …