Type III interferons (IFN), IFN-λ or IL-28/29, are new members of the IFN super-family. Except
for using distinct receptors, type I and type III IFNs share the same major post receptor …

Highlights•Type III interferons are antiviral factors that are expressed in response to
numerous viral infections.•Type III interferons are most crucial for controlling viral infections …

Type III interferon (IFN) or IFN-λ is a recently discovered family of IFNs that signal through
the same downstream transcription factors as type I IFN but use a separate receptor complex …

Virus replication induces the expression of antiviral type I (IFN-αβ) and type III (IFN-λ1–3 or
IL-28A/B and IL-29) IFN genes via TLR-dependent and-independent pathways. Although …

IFN-λ4 is a novel type-III interferon with strong clinical significance in humans. Only a subset
of individuals—up to 10% of Asians, 50% of Europeans, and 90% of Africans—carry the ΔG …

Type III interferons or IFN-λs, are composed of 4 members: IFN-λ1, IFN-λ2, IFN-λ3, and IFN-
λ4. IFN-λs are master protectors against mucosal viral infections due to the preferential …

The IFNL4 gene is a recently discovered type III interferon, which in a significant fraction of
the human population harbours a frameshift mutation abolishing the IFNλ4 ORF. The …

Interferons lambda (IFN-λ) are the most recently defined members of the class III cytokine
family. To investigate whether IFN-λ2 and IFN-λ3 displayed antiviral activity against …

With increasing interest in alternative options to interferon‐alpha‐based treatments, IFN‐λ
has shown therapeutic promise in a variety of diseases. Although the antiviral activity of IFN …

Type III interferons (IFN-lambdas, IFN-λs) are important antiviral cytokines that can also
modulate immune responses by acting through a heterodimeric receptor composed of the …