Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19
ER Mann, M Menon, SB Knight, JE Konkel… - Science …, 2020 - science.org
COVID-19 pathogenesis is associated with an exaggerated immune response. However, the
specific cellular mediators and inflammatory components driving diverse clinical disease …
specific cellular mediators and inflammatory components driving diverse clinical disease …
[HTML][HTML] Single-cell sequencing of peripheral mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients
Summary The coronavirus disease 2019 (COVID-19) pandemic poses a current world-wide
public health threat. However, little is known about its hallmarks compared to other infectious …
public health threat. However, little is known about its hallmarks compared to other infectious …
Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …
[HTML][HTML] Major alterations to monocyte and dendritic cell subsets lasting more than 6 months after hospitalization for COVID-19
Introduction After more than two years the Coronavirus disease-19 (COVID-19) pandemic
continues to burden healthcare systems and economies worldwide, and it is evident that the …
continues to burden healthcare systems and economies worldwide, and it is evident that the …
Severe COVID-19 is marked by a dysregulated myeloid cell compartment
J Schulte-Schrepping, N Reusch, D Paclik, K Baßler… - Cell, 2020 - cell.com
Summary Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract
infection, however, a subset of patients progress to severe disease and respiratory failure …
infection, however, a subset of patients progress to severe disease and respiratory failure …
Alterations in circulating monocytes predict COVID-19 severity and include chromatin modifications still detectable six months after recovery
A Utrero-Rico, C Gonzalez-Cuadrado… - Biomedicines, 2021 - mdpi.com
An early analysis of circulating monocytes may be critical for predicting COVID-19 course
and its sequelae. In 131 untreated, acute COVID-19 patients at emergency room arrival …
and its sequelae. In 131 untreated, acute COVID-19 patients at emergency room arrival …
[HTML][HTML] Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions
COVID-19 has become a global pandemic. Immune dysregulation has been implicated, but
immune responses remain poorly understood. We analyzed 71 COVID-19 patients …
immune responses remain poorly understood. We analyzed 71 COVID-19 patients …
Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19
NAF Janssen, I Grondman… - The Journal of …, 2021 - academic.oup.com
The clinical spectrum of COVID-19 varies and the differences in host response
characterizing this variation have not been fully elucidated. COVID-19 disease severity …
characterizing this variation have not been fully elucidated. COVID-19 disease severity …
Severe COVID-19 recovery is associated with timely acquisition of a myeloid cell immune-regulatory phenotype
AC Trombetta, GB Farias, AMC Gomes… - Frontiers in …, 2021 - frontiersin.org
After more than one year since the COVID-19 outbreak, patients with severe disease still
constitute the bottleneck of the pandemic management. Aberrant inflammatory responses …
constitute the bottleneck of the pandemic management. Aberrant inflammatory responses …
A dynamic COVID-19 immune signature includes associations with poor prognosis
Improved understanding and management of COVID-19, a potentially life-threatening
disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward …
disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward …