Abstract Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps
protons across intracellular and plasma membranes. It consists of a large multi‐subunit …

The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis
to proton transport into intracellular compartments and across the plasma membrane. They …

Up-regulated aerobic glycolysis is a hallmark of malignant cancers. Little is understood
about the reasons why malignant tumors up-regulate glycolysis and acidify their …

Abstract The vacuolar H+ ATPase (V-ATPase) is a proton pump responsible for acidification
of cellular microenvironments, an activity exploited by tumors to survive, proliferate and …

Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …

Abstract Development of resistance to platinum compounds significantly hinders successful
ovarian cancer (OVCA) treatment. In tumor cells, dysregulated pH gradient across cell …

Vacuolar H+-translocating ATPase (V-ATPase) is a universal proton pump, and its activity is
required for a variety of cell biological processes, such as membrane trafficking, receptor …

The vacuolar (H+)-ATPases (V-ATPases) are ATP-dependent proton pumps that acidify
intracellular compartments and are also present at the plasma membrane. They function in …

Vacuolar-type H+-adenosine triphosphatase (V-ATPase) is one of the most fundamental
enzymes in nature. V-ATPases are responsible for the regulation of proton concentration in …

Vacuolar H+‐ATPases (V‐ATPases) are large multisubunit proton pumps that are required
for housekeeping acidification of membrane‐bound compartments in eukaryotic cells …