Lysine 56 acetylation in the helical core of histone H3 opens yeast chromatin and enables
histone gene transcription, DNA replication, and DNA repair and prevents epigenetic …

Background Transcription regulation in pluripotent embryonic stem (ES) cells is a complex
process that involves multitude of regulatory layers, one of which is post-translational …

Background Histone post-translational modifications are critical determinants of chromatin
structure and function, impacting multiple biological processes including DNA transcription …

Compared with histone H3, acetylation of H4 tails has not been well studied, especially in
mammalian cells. Yet, H4K16 acetylation is of particular interest because of its ability to …

Histone acetylation is generally associated with gene activation and chromatin
decondensation. Recent mass spectrometry analysis has revealed that histone H4 lysine 20 …

We mapped Polycomb-associated H3K27 trimethylation (H3K27me3) and Trithorax-
associated H3K4 trimethylation (H3K4me3) across the whole genome in human embryonic …

Lysine acetylation of histones defines the epigenetic status of human embryonic stem cells
and orchestrates DNA replication, chromosome condensation, transcription, telomeric …

Before zygotic genome activation (ZGA), the quiescent genome undergoes reprogramming
to transition into the transcriptionally active state. However, the mechanisms underlying …

The linker histone H1 is a key player in chromatin organization, yet our understanding of the
regulation of H1 functions by post-translational modifications is very limited. We provide here …

Embryonic stem cell (ESC) chromatin is characterized by a unique set of histone
modifications, including enrichment for H3 lysine 9 acetylation (H3K9ac). Recent studies …