N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases

Y Chen, X Ouyang, X Yu, P Novák, L Zhou… - Journal of …, 2021 - Springer
Abstract N6-methyladenosine (m 6 A) is the most abundant and prevalent epigenetic
modification of mRNA in mammals. This dynamic modification is regulated by m 6 A …

N6-methyladenosine RNA methylation in cardiovascular diseases

C Liu, L Gu, W Deng, Q Meng, N Li, G Dai… - Frontiers in …, 2022 - frontiersin.org
N6-methyladenosine (m6A) modification is the most universal and abundant post-
transcriptional modification of eukaryotic RNA and occurs mainly at the consensus motif RR …

Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system

K Zhao, C Yang, P Li, W Sun, X Kong - Journal of Zhejiang University …, 2020 - Springer
As the most prevalent and abundant transcriptional modification in the eukaryotic genome,
the continuous and dynamic regulation of N 6-methyladenosine (m 6 A) has been shown to …

m6A methylation in cardiovascular diseases: from mechanisms to therapeutic potential

L Li, N Xu, J Liu, Z Chen, X Liu, J Wang - Frontiers in genetics, 2022 - frontiersin.org
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide.
Recent studies have shown that n6-methyladenosine (m6A) plays a major role in …

m6A RNA methylation in cardiovascular diseases

S Wu, S Zhang, X Wu, X Zhou - Molecular Therapy, 2020 - cell.com
Cardiovascular diseases (CVDs) remain the leading cause of death and disability
worldwide, despite marked improvements in prevention, diagnosis, and early intervention …

Emerging role of m6A modification in cardiovascular diseases

L Peng, T Long, F Li, Q Xie - Cell Biology International, 2022 - Wiley Online Library
Cardiovascular diseases (CVDs) contribute to the leading cause of death worldwide.
Despite significant improvements in CVDs diagnosis and treatment, a continued effort to …

Relevance of N6-methyladenosine regulators for transcriptome: Implications for development and the cardiovascular system

WK Sweaad, FM Stefanizzi… - Journal of Molecular and …, 2021 - Elsevier
Abstract N6-methyladenosine (m6A) is the most abundant and well-studied internal
modification of messenger RNAs among the various RNA modifications in eukaryotic cells …

mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification

R Kumari, P Ranjan, ZG Suleiman… - Cardiovascular …, 2022 - academic.oup.com
Among several known RNA modifications, N6‐methyladenosine (m6A) is the most studied
RNA epitranscriptomic modification and controls multiple cellular functions during …

Emerging roles and mechanism of m6A methylation in cardiometabolic diseases

Z Xu, B Lv, Y Qin, B Zhang - Cells, 2022 - mdpi.com
Cardiometabolic diseases (CMDs) are currently the leading cause of death and disability
worldwide, and their underlying regulatory mechanisms remain largely unknown. N6 …

Epitranscriptomics in the Heart: a Focus on m6A

JZ Longenecker, CJ Gilbert, VA Golubeva… - Current heart failure …, 2020 - Springer
Abstract Purpose of Review Post-transcriptional modifications are key regulators of gene
expression that allow the cell to respond to environmental stimuli. The most abundant …