The glymphatic system is a recently discovered network unique to the central nervous
system that allows for dynamic exchange of interstitial fluid (ISF) and cerebrospinal fluid …

Until recently, it was thought that there were no lymphatic vessels in the central nervous
system (CNS). Therefore, all metabolic processes were assumed to take place only in the …

Objective The glymphatic pathway, characterised as a cerebral drainage system, influences
cognitive function in neurodegenerative diseases; however, evidence is limited in a normal …

The discovery of the glial-lymphatic or glymphatic fluid clearance pathway in the rodent
brain led researchers to search for a parallel system in humans and to question the …

Embryonic genetic mechanisms are present in the brain and ready to be placed into action
upon cellular injury, termed the response to injury wound-healing (RTIWH) mechanism …

Age-related neurodegenerative diseases are a growing burden to society, and many are
sporadic, meaning that the environment, diet and lifestyle play significant roles …

Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we
demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause …

The glymphatic system hypothesis is a concept describing the clearance of waste products
from the brain. The term “glymphatic system” combines the glial and lymphatic systems and …

Brain fluids are rigidly regulated to provide stable environments for neuronal function, eg,
low K+, Ca 2+, and protein to optimise signalling and minimise neurotoxicity. At the same …

The newly discovered glymphatic system acts as pseudolymphatic vessels subserving brain
waste clearance and is functionally dependent on astrocytic aquaporin‐4 channels. The …