Glymphatic system evaluation using diffusion tensor imaging in patients with traumatic brain injury

JH Park, YJ Bae, JS Kim, WS Jung, JW Choi, TH Roh… - Neuroradiology, 2023 - Springer
Purpose Glymphatic system dysfunction has been reported in animal models of traumatic
brain injury (TBI). This study aimed to evaluate the activity of the human glymphatic system …

Neurovascular-glymphatic dysfunction and white matter lesions

B Sabayan, RGJ Westendorp - Geroscience, 2021 - Springer
Cerebral white matter lesions (WML) represent a spectrum of age-related structural changes
that are identified as areas of white matter high signal intensity on brain magnetic resonance …

[HTML][HTML] Glymphatic Drainage Blocking Aggravates Brain Edema, Neuroinflammation via Modulating TNF-α, IL-10, and AQP4 After Intracerebral Hemorrhage in Rats

X Liu, G Wu, N Tang, L Li, C Liu, F Wang… - Frontiers in Cellular …, 2021 - frontiersin.org
Objective: The “Glymphatic” system, a network of perivascular tunnels wrapped by astrocyte
endfeet, was reported to be closely associated with the diseases of the central nervous …

[HTML][HTML] Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease

MJ Simon, JJ Iliff - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2016 - Elsevier
Cerebrospinal fluid (CSF) circulation and turnover provides a sink for the elimination of
solutes from the brain interstitium, serving an important homeostatic role for the function of …

Neurofluids and the glymphatic system: anatomy, physiology, and imaging

DJJ Wang, J Hua, D Cao, ML Ho - The British journal of …, 2023 - academic.oup.com
First described in 2012, the glymphatic system is responsible for maintaining homeostasis
within the central nervous system, including nutrient delivery, waste clearance, and …

Association of cognition and brain reserve in aging and glymphatic function using diffusion tensor image-along the perivascular space (DTI-ALPS)

WC Hsiao, HI Chang, SW Hsu, CC Lee, SH Huang… - Neuroscience, 2023 - Elsevier
The glymphatic system is a fluid-clearance pathway that clears cerebral waste products, and
its dysfunction has been associated with protein aggregation diseases such as Alzheimer's …

[HTML][HTML] Blood–brain barrier pathophysiology following traumatic brain injury

L Price, C Wilson, G Grant - Translational research in traumatic …, 2016 - ncbi.nlm.nih.gov
In the past, the neuron has been the focal point of brain injury research. However, in recent
years, the pathophysiology of the blood-brain barrier (BBB) has become increasingly more …

Cerebral glucagon‐like peptide‐1 receptor activation alleviates traumatic brain injury by glymphatic system regulation in mice

C Lv, S Han, Z Sha, M Liu, S Dong… - CNS Neuroscience …, 2023 - Wiley Online Library
Aim We aimed to assess the effects of cerebral glucagon‐like peptide‐1 receptor (GLP‐1R)
activation on the glymphatic system and whether this effect was therapeutic for traumatic …

[HTML][HTML] Persistent malfunction of glymphatic and meningeal lymphatic drainage in a mouse model of subarachnoid hemorrhage

T Pu, W Zou, W Feng, Y Zhang, L Wang… - Experimental …, 2019 - ncbi.nlm.nih.gov
Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular event that often is
followed by permanent brain impairments. It is necessary to explore the pathogenesis of …

[HTML][HTML] Imaging the neurovascular unit in health and neurodegeneration: a scoping review of interdependencies between MRI measures

E Rowsthorn, W Pham, MR Nazem-Zadeh… - Fluids and Barriers of …, 2023 - Springer
The neurovascular unit (NVU) is a complex structure that facilitates nutrient delivery and
metabolic waste clearance, forms the blood–brain barrier (BBB), and supports fluid …