Expression of TRK-T1 oncogene induces differentiation of PC12 cells
A Greco, R Orlandi, C Mariani, C Miranda… - Cell growth and …, 1993 - AACR
The TRK-T1 oncogene, isolated from a human thyroid carcinoma, represents a rearranged
form of the high affinity nerve growth factor (NGF) receptor encoded by the NTRK1 gene; it is …
form of the high affinity nerve growth factor (NGF) receptor encoded by the NTRK1 gene; it is …
The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain
A Greco, C Mariani, C Miranda, A Lupas… - … and cellular biology, 1995 - Am Soc Microbiol
Oncogenic rearrangements of the NTRK1 gene (also designated TRKA), encoding one of
the receptors for the nerve growth factor, are frequently detected in thyroid carcinomas. Such …
the receptors for the nerve growth factor, are frequently detected in thyroid carcinomas. Such …
The trk family of oncogenes and neurotrophin receptors.
F Lamballe, R Klein, M Barbacid - Princess Takamatsu symposia, 1991 - europepmc.org
To date more than twenty five different oncogenes have been identified in human
neoplasias. One of these oncogenes is trk, a transforming gene originally isolated from a …
neoplasias. One of these oncogenes is trk, a transforming gene originally isolated from a …
The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3
C Cordon-Cardo, P Tapley, S Jing, V Nanduri… - Cell, 1991 - cell.com
The product of the trk proto-oncogene encodes a receptor for nerve growth factor (NGF).
Here we show that NGF is a powerful mitogen that can induce resting NIH 3T3 cells to enter …
Here we show that NGF is a powerful mitogen that can induce resting NIH 3T3 cells to enter …
Role of the TFG N-terminus and coiled-coil domain in the transforming activity of the thyroid TRK-T3 oncogene
A Greco, L Fusetti, C Miranda, R Villa, S Zanotti… - Oncogene, 1998 - nature.com
The thyroid TRK-T3 oncogene results from the fusion of the tyrosine kinase (TK) domain of
NTRK1 (one of the receptors for the Nerve Growth Factor) on chromosome 1 to sequences …
NTRK1 (one of the receptors for the Nerve Growth Factor) on chromosome 1 to sequences …
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3
R Klein, V Nanduri, S Jing, F Lamballe, P Tapley… - Cell, 1991 - cell.com
Summary trkB is a tyrosine protein kinase gene highly related to trk, a proto-oncogene that
encodes a receptor for nerve growth factor (NGF) and neurotrophin-3(NT-3). t&B expression …
encodes a receptor for nerve growth factor (NGF) and neurotrophin-3(NT-3). t&B expression …
Transfection of TRK-A into human neuroblastoma cells restores their ability to differentiate in response to nerve growth factor.
E Lavenius, C Gestblom, I Johansson… - Cell growth & …, 1995 - europepmc.org
Human neuroblastoma cell lines frequently express the TRK-A proto-oncogene and bind
nerve growth factor (NGF) but do not differentiate when exposed to NGF. Transient …
nerve growth factor (NGF) but do not differentiate when exposed to NGF. Transient …
The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines
DM Loeb, J Maragos, D Martin-Zanca, MV Chao… - Cell, 1991 - cell.com
The trk tyrosine kinase proto-oncogene product gp140p'“'o” k binds nerve growth factor
(NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine …
(NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine …
TRK oncogenes in papillary thyroid carcinoma
A Greco, E Roccato, MA Pierotti - Molecular basis of thyroid cancer, 2004 - Springer
The NTRK1 gene encodes the high affinity receptor for Nerve Growth Factor, and its action
regulates neural development and differentiation. Deregulation of NTRK1 activity is …
regulates neural development and differentiation. Deregulation of NTRK1 activity is …
On the Right Track to the NGF Receptor: The trk oncogene may provide the missing link that will help researchers understand how nerve growth factor transmits its …
M Barinaga - Science, 1991 - science.org
The trk oncogene may provide the missing link that will help researchers understand how
nerve growth factor transmits its signals into nerve cells understanding of the metabolic …
nerve growth factor transmits its signals into nerve cells understanding of the metabolic …