Variations in drug transporter activities, caused by genetic polymorphism and drug–drug
interactions (DDIs), alter the systemic exposure of substrate drugs, leading to differences in …

Clinical reports on transporter-mediated drug–drug interactions (TP-DDIs) have rapidly
accumulated and regulatory guidance/guidelines recommend that sponsors consider …

Background: Drug-Drug Interactions (DDI) by modulation of drug transporters or drug
metabolizing enzymes are common in multi-drug therapy. DDI potential of any new drug is …

Comprehensive characterization of transporter mediated drug‐drug interactions (DDIs) is
important to formulate clinical management strategies and ensure the safe and effective use …

Membrane transporters play an important role in the absorption, distribution, metabolism,
and excretion of xenobiotic substrates, as well as endogenous compounds. The evaluation …

Drug transporters can govern the absorption, distribution, metabolism, and excretion of
substrate drugs and endogenous substances. Investigations to examine their potential …

The evaluation of transporter-mediated drug–drug interactions (DDIs) during drug
development and post-approval contributes to benefit–risk assessment and helps formulate …

Introduction: It is becoming increasingly evident that transporters play an important role in
the absorption, distribution and elimination of many drugs. Different approaches have been …

Drug–drug interactions are a major concern not only during clinical practice, but also in drug
development. Due to limitations of in vitro–in vivo predictions of transporter-mediated drug …

Drug transporters are recognized widely for their role in clinical pharmacokinetics and drug–
drug interactions (DDIs). This has provided impetus to the inclusion of transporter substrate …