The generation of induced pluripotent stem cells from adult somatic cells by ectopic
expression of key transcription factors holds significant medical promise. However, current …

Despite years of research, the reprogramming of human somatic cells to pluripotency
remains a slow, inefficient process, and a detailed mechanistic understanding of …

The mysteries of induced pluripotency: where will they lead? | Nature Methods Skip to main
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With relatively low efficiency, differentiated cells can be reprogrammed to a pluripotent state
by ectopic expression of a few transcription factors. An understanding of the mechanisms …

When pluripotent cells are exposed to a uniform culture environment they routinely display
heterogeneous gene expression. Aspects of this heterogeneity, such as Nanog expression …

Living organisms, from virus to human, rely on the transcription machinery to express
specific parts of their genomes to execute critical biological functions during their life cycle …

The ability of pluripotent stem cells to differentiate into all cell types of an organism has
received widespread attention in basic and clinical research and holds tremendous potential …

Pluripotency and self-renewal are the defining traits of embryonic stem cells (ESCs) and this
status quo is maintained by the core transcription factors Oct4, Sox2, and Nanog. Genome …

The divergence of the pluripotent inner cell mass and extraembryonic trophectoderm from
an apparently homogenous population of cells is a decisive event in mammalian …

Pluripotency in human embryonic stem cells (hESCs) and induced pluripotent stem cells
(iPSCs) is regulated by three transcription factors—OCT3/4, SOX2, and NANOG. To fully …