The release of inflammatory mediators from immune and glial cells either in the peripheral or
CNS may have an important role in the development of physiopathological processes such …

Cytokines, essential mediators of inflammatory and immune responses, play an important
role in the pathophysiological processes associated with neuropathic pain following …

Abstract Interleukin‐18 (IL‐18) is an important cytokine in innate immunity and in the
induction phase of autoimmunity. We report the expression of IL‐18 mRNA and protein after …

Abstract Interleukin‐10 (IL‐10) exerts a wide spectrum of regulatory activities in the immune
and inflammatory response. The aim of this study was to investigate the role of endogenous …

Interleukin (IL)-17A, a recently described novel T cell cytokine, orchestrates inflammation in
a variety of immune-mediated diseases. In the present investigation, we analyzed the …

Immune cells are critical in promoting neuroinflammation and neuropathic pain and in
facilitating pain resolution, depending on their inflammatory and immunoregulatory cytokine …

Interleukin (IL)-18 is an important regulator of innate and acquired immune responses. Here
we show that both the IL-18 and IL-18 receptor (IL-18R), which are induced in spinal dorsal …

Intraspinal injection of quisqualic acid (QUIS) produces excitotoxic injury with
pathophysiological characteristics similar to those associated with ischemic and traumatic …

Although reactive glia formation after neuronal degeneration or traumatic damage is one of
the hallmarks of central nervous system (CNS) injury, we have little information on the …

The mechanisms underlying neuropathic pain caused by nerve injury are not well
understood. Inflammatory responses in injured nerves are likely to be key contributing …