Plasma membranes of eukaryotic cells are not uniform, possessing distinct cholesterol-and
sphingolipid-rich lipid raft microdomains which constitute critical sites for signal transduction …

CD2 mediates T cell adhesion via its ectodomain and signal transduction utilizing its 117-
amino acid cytoplasmic tail. Here we show that a significant fraction of human CD2 …

In T lymphocytes, lipid rafts are preferred sites for signal transduction initiation and
amplification. Many cell membrane receptors, such as the TCR, coreceptors, and accessory …

▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

Invariant natural killer T (iNKT) cells recognize glycolipid antigens presented by CD1d, an
antigen presenting protein structurally similar to MHC class I. Stimulation of iNKT cells by …

The CD1 family of glycosylated cell surface receptors binds and presents lipid antigens for T
cell recognition and activation. Crystal structures of CD1-lipid complexes reveal differences …

Together with peptides, T lymphocytes respond to hydrophobic molecules, mostly lipids,
presented by the non‐classical CD 1 family (CD 1a–e). These molecules have evolved …

CD1d is an MHC class I-like membrane glycoprotein that presents lipid Ags to NKT cells.
Despite intensive biochemical, genetic, and structural studies, the endogenous lipids …

Accumulating evidence strongly supports the role of lipid rafts in the regulation of T‐
lymphocyte activation, but the organization and molecular composition of these cholesterol …

Cluster of differentiation 1 (CD1) is a family of cell-surface glycoproteins that present lipid
antigens to T cells. Humans have five CD1 isoforms. CD1a is distinguished by the small …