Wilms tumour has been reported in association with over 50 different clinical conditions and
several abnormal constitutional karyotypes. Conclusive evidence of an increased risk of …

We report here 24 new Wilms tumor (WT) patients with germline WT1 alterations and a
synopsis of our own previously described and literature cases in whom age of tumor‐onset …

Abstract Background Wilms Tumor (WT) can occur in association with tumor predisposition
syndromes and/or with clinical malformations. These associations have not been fully …

Wilms tumor (WT), an embryonic tumor arising from undifferentiated renal mesenchyme, has
been a productive model for understanding the role of genes in both tumorigenesis and …

Wilms tumor is genetically heterogeneous, and until recently only one Wilms tumor gene
was known, WT1 at 11p13. However, WT1 is altered in only∼ 20% of Wilms tumors …

Wilms tumor (WT), a sporadic and familial childhood kidney tumor, is genetically
heterogeneous. One WT gene, WT1 at 11p13, has been cloned, but only a minority of WTs …

Publisher Summary Wilms' tumor presents a genetic pattern that may be intermediate in
complexity, between the single-locus disease exemplified by retinoblastoma and the …

The past decade has witnessed substantial growth in our knowledge of the genes and loci
that are altered in Wilms tumor. Although Wilms tumor was one of the original paradigms of …

Homozygous deletions in Wilms' tumor DNA have been a key step in the identification and
isolation of the WT1 gene. Several additional loci are also postulated to contribute to Wilms' …

Genetic alterations in tumor suppressor genes are believed to play an important role in the
initiation of childhood and adult malignancies. Tumor‐specific loss of heterozygosity for …