A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2

Y Wu, F Wang, C Shen, W Peng, D Li, C Zhao, Z Li, S Li… - Science, 2020 - science.org
Neutralizing antibodies could potentially be used as antivirals against the coronavirus
disease 2019 (COVID-19) pandemic. Here, we report isolation of four human-origin …

[HTML][HTML] Characterization of neutralizing antibodies from a SARS-CoV-2 infected individual

E Seydoux, LJ Homad, AJ MacCamy, KR Parks… - BioRxiv, 2020 - ncbi.nlm.nih.gov
B cells specific for the SARS-CoV-2 S envelope glycoprotein spike were isolated from a
COVID-19-infected subject using a stabilized spike-derived ectodomain (S2P) twenty-one …

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Y Chen, X Zhao, H Zhou, H Zhu, S Jiang… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …

A bispecific antibody targeting RBD and S2 potently neutralizes SARS-CoV-2 Omicron and other variants of concern

M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants,
especially the Omicron variant, have impaired the efficacy of existing vaccines and most …

Neutralizing antibodies for the treatment of COVID-19

S Jiang, X Zhang, Y Yang, PJ Hotez, L Du - Nature biomedical …, 2020 - nature.com
Neutralizing antibodies for the treatment of COVID-19 | Nature Biomedical Engineering Skip to
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Structures of SARS-CoV-2 B. 1.351 neutralizing antibodies provide insights into cocktail design against concerning variants

S Du, P Liu, Z Zhang, T Xiao, A Yasimayi, W Huang… - Cell research, 2021 - nature.com
Dear Editor, The spread of the SARS-CoV-2 variants, especially the global variants of
concern (VOCs), could seriously dampen our efforts to tackle the COVID-19 pandemic. The …

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

JL Torres, G Ozorowski, E Andreano… - Proceedings of the …, 2022 - National Acad Sciences
As the coronavirus disease 2019 (COVID-19) pandemic continues, there is a strong need for
highly potent monoclonal antibodies (mAbs) that are resistant against severe acute …

[HTML][HTML] Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay

E Lopez, ER Haycroft, A Adair, FL Mordant, MT O'Neill… - JCI insight, 2021 - ncbi.nlm.nih.gov
The SARS-CoV-2 receptor binding domain (RBD) is both the principal target of neutralizing
antibodies and one of the most rapidly evolving domains, which can result in the emergence …

Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

S Wang, Y Peng, R Wang, S Jiao, M Wang… - Nature …, 2020 - nature.com
Efficacious interventions are urgently needed for the treatment of COVID-19. Here, we report
a monoclonal antibody (mAb), MW05, with SARS-CoV-2 neutralizing activity by disrupting …

Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016

TN Starr, AJ Greaney, AS Dingens, JD Bloom - Cell Reports Medicine, 2021 - cell.com
Monoclonal antibodies and antibody cocktails are a promising therapeutic and prophylaxis
for coronavirus disease 2019 (COVID-19). However, ongoing evolution of severe acute …