Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline

M Tuccori, S Ferraro, I Convertino, E Cappello… - MAbs, 2020 - Taylor & Francis
Monoclonal antibody (mAb) therapy has been previously exploited for viral infections, such
as respiratory syncytial virus pneumonia and Ebolavirus disease. In the ongoing COVID-19 …

[HTML][HTML] COVID-19-neutralizing antibodies predict disease severity and survival

WF Garcia-Beltran, EC Lam, MG Astudillo, D Yang… - Cell, 2021 - cell.com
Summary Coronavirus disease 2019 (COVID-19) exhibits variable symptom severity ranging
from asymptomatic to life-threatening, yet the relationship between severity and the humoral …

Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters

MS Piepenbrink, JG Park, FS Oladunni… - Cell Reports …, 2021 - cell.com
SARS-CoV-2 infection results in viral burden in the respiratory tract, enabling transmission
and leading to substantial lung pathology. The 1212C2 fully human monoclonal antibody …

A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection

P Zhou, M Yuan, G Song, N Beutler… - Science translational …, 2022 - science.org
Broadly neutralizing antibodies (bnAbs) to coronaviruses (CoVs) are valuable in their own
right as prophylactic and therapeutic reagents to treat diverse CoVs and as templates for …

[HTML][HTML] Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers, and convalescent plasma donors

C Zeng, JP Evans, R Pearson, P Qu, YM Zheng… - JCI insight, 2020 - ncbi.nlm.nih.gov
Rapid and specific antibody testing is crucial for improved understanding, control, and
treatment of COVID-19 pathogenesis. Herein, we describe and apply a rapid, sensitive, and …

SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus

M Dogan, L Kozhaya, L Placek, C Gunter… - Communications …, 2021 - nature.com
Abstract Development of antibody protection during SARS-CoV-2 infection is a pressing
question for public health and for vaccine development. We developed highly sensitive …

A neutralizing monoclonal antibody for hospitalized patients with Covid-19

Activ-3/Tico Ly-CoV555 Study … - New England Journal of …, 2021 - Mass Medical Soc
Background LY-CoV555, a neutralizing monoclonal antibody, has been associated with a
decrease in viral load and the frequency of hospitalizations or emergency department visits …

Neutralizing antibodies against SARS-CoV-2 and other human coronaviruses

S Jiang, C Hillyer, L Du - Trends in immunology, 2020 - cell.com
Coronavirus (CoV) disease 2019 (COVID-19) caused by severe acute respiratory syndrome
(SARS)-CoV-2 (also known as 2019-nCoV) is threatening global public health, social …

[HTML][HTML] Neutralizing monoclonal antibodies for treatment of COVID-19

PC Taylor, AC Adams, MM Hufford… - Nature Reviews …, 2021 - nature.com
Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) have been developed and are now under evaluation in clinical …

SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variants

F Tea, A Ospina Stella, A Aggarwal… - PLoS …, 2021 - journals.plos.org
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antibody
neutralization response and its evasion by emerging viral variants and variant of concern …