The current paradigm for the etiology of autoimmune rheumatic disease is that several
preclinical stages precede the onset of clinically apparent disease. When individuals at …

Abstract Background According to the Genetic Analysis Workshops (GAW), hundreds of
thousands of SNPs have been tested for association with rheumatoid arthritis. Traditional …

The rheumatic diseases are a family of chronic systemic illnesses characterized by immune
dysregulation that ultimately lead to inflammation, internal organ injury, and in some cases …

Abstract Evaluation of the association between single-nucleotide polymorphisms (SNPs)
and disease outcomes is widely used to identify genetic risk factors for complex diseases …

Objective Immune-mediated inflammatory diseases (IMIDs) are heterogeneous and complex
conditions with overlapping clinical symptoms and elevated familial aggregation, which …

We compare and contrast case-only designs for detecting gene× gene (G× G) interaction in
rheumatoid arthritis (RA) using the genome-wide data provided by Genetic Analysis …

Objectives Nearly 110 susceptibility loci for rheumatoid arthritis (RA) with modest effect sizes
have been identified by population-based genetic association studies, suggesting a large …

Rheumatoid arthritis (RA), the most common autoimmune diseases, is a systemic, chronic
inflammatory disease, which is primarily involves the joints affecting up to 1% of the …

Genotypic variability based genome-wide association studies (vGWASs) can identify
potentially interacting loci without prior knowledge of the interacting factors. We report a two …

Background Clinical and epidemiological studies have suggested systemic lupus
erythematosus (SLE) and rheumatoid arthritis (RA) are comorbidities and common genetic …