Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement …
Integrative gene network approaches enable new avenues of exploration that implicate
causal genes in sporadic late-onset Alzheimer's disease (LOAD) pathogenesis, thereby …
causal genes in sporadic late-onset Alzheimer's disease (LOAD) pathogenesis, thereby …
Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2
JV Haure-Mirande, M Audrain, ME Ehrlich… - Molecular …, 2022 - Springer
TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially
described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is …
described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is …
Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models
Background Cerebral amyloidosis, neuroinflammation, and tauopathy are key features of
Alzheimer's disease (AD), but interactions among these features remain poorly understood …
Alzheimer's disease (AD), but interactions among these features remain poorly understood …
Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while …
TYROBP/DAP12 forms complexes with ectodomains of immune receptors (TREM2, SIRPβ1,
CR3) associated with Alzheimer's disease (AD) and is a network hub and driver in the …
CR3) associated with Alzheimer's disease (AD) and is a network hub and driver in the …
Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice
Abstract Introduction Microglial TYROBP (DAP12) is a network hub and driver in sporadic
late‐onset Alzheimer's disease (AD). TYROBP is a cytoplasmic adaptor for TREM2 and …
late‐onset Alzheimer's disease (AD). TYROBP is a cytoplasmic adaptor for TREM2 and …
[HTML][HTML] Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease
The genetics of complex disease produce alterations in the molecular interactions of cellular
pathways whose collective effect may become clear through the organized structure of …
pathways whose collective effect may become clear through the organized structure of …
Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology
JV Haure-Mirande, M Audrain, T Fanutza, SH Kim… - Acta …, 2017 - Springer
Conventional genetic approaches and computational strategies have converged on immune-
inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer's …
inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer's …
A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease
Abstract Background Late-onset Alzheimer's disease (LOAD) is the most common form of
dementia worldwide. To date, animal models of Alzheimer's have focused on rare familial …
dementia worldwide. To date, animal models of Alzheimer's have focused on rare familial …
Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
presence of extracellular amyloid plaques consisting of Amyloid-β peptide (Aβ) aggregates …
presence of extracellular amyloid plaques consisting of Amyloid-β peptide (Aβ) aggregates …
Mapping the gene network landscape of Alzheimer's disease through integrating genomics and transcriptomics
Integration of multi-omics data with molecular interaction networks enables elucidation of the
pathophysiology of Alzheimer's disease (AD). Using the latest genome-wide association …
pathophysiology of Alzheimer's disease (AD). Using the latest genome-wide association …