Both previous infection and vaccination have been shown to provide potent protection from COVID-19. However, there are concerns that waning immunity and viral variation may lead …
The global supply of COVID-19 vaccines remains limited. An understanding of the immune response that is predictive of protection could facilitate rapid licensure of new vaccines. Data …
A correlate of protection for SARS-CoV-2 vaccines is urgently needed | Nature Medicine Skip to main content Thank you for visiting nature.com. You are using a browser version with limited …
SARS-CoV-2 escaped natural immunity, raising questions about vaccines and therapies | Nature Medicine Skip to main content Thank you for visiting nature.com. You are using a …
K Vanshylla, V Di Cristanziano, F Kleipass, F Dewald… - Cell host & …, 2021 - cell.com
Understanding antibody-based SARS-CoV-2 immunity is critical for overcoming the COVID- 19 pandemic and informing vaccination strategies. We evaluated SARS-CoV-2 antibody …
Summary Background Several SARS-CoV-2 variants of concern have been identified that partly escape serum neutralisation elicited by current vaccines. Studies have also shown …
AM Arvin, K Fink, MA Schmid, A Cathcart, R Spreafico… - Nature, 2020 - nature.com
Antibody-dependent enhancement (ADE) of disease is a general concern for the development of vaccines and antibody therapies because the mechanisms that underlie …
VV Edara, K Floyd, L Lai, M Gardner, W Hudson… - MedRxiv, 2021 - medrxiv.org
Antibody responses against the SARS-CoV-2 Spike protein correlate with protection against COVID-19. Serum neutralizing antibodies appear early after symptom onset following SARS …
Antibodies elicited in response to infection undergo somatic mutation in germinal centers that can result in higher affinity for the cognate antigen. To determine the effects of somatic …