MAVS and MITA are essential adaptor proteins mediating innate antiviral immune
responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays …

VISA (also known as MAVS, IPS-1 and Cardif) is an essential adaptor protein in innate
immune response to RNA virus. The protein level of VISA is delicately regulated before and …

Virus infection induces host antiviral responses including induction of type I IFNs.
Transcription factor IFN regulatory factor 3 (IRF3) plays an essential role and is tightly …

The tripartite motif-containing (TRIM) proteins represent the largest E3 ubiquitin ligase
family. The multifaceted roles of TRIM38 in innate immunity and inflammation have been …

Highlights•TRIM proteins are E3 ubiquitin ligases that target specific substrates.•TRIM
proteins regulate antiviral cytokine induction or autophagy.•Several TRIM proteins directly …

Influenza A virus (IAV) is a highly transmissible respiratory pathogen and a major cause of
morbidity and mortality around the world. Nucleoprotein (NP) is an abundant IAV protein …

The tripartite motif-containing (TRIM) proteins have emerged as a new class of host antiviral
restriction factors, with several demonstrating roles in regulating innate antiviral responses …

The innate immune system responds rapidly to protect against viral infections, but an
overactive response can cause harmful damage. To avoid this, the response is tightly …

Abstract RIG‐I‐MAVS antiviral signaling represents an important pathway to stimulate
interferon production and confer innate immunity to the host. Upon binding to viral RNA and …

The mitochondrial anti-viral signaling protein (MAVS), also known as CARDIF, IPS-1,
KIAA1271 and VISA, is a mitochondria associated protein that regulates type I interferon …