[HTML][HTML] SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies
Abstract The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health
crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding domain …
crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding domain …
[PDF][PDF] The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies
Monoclonal antibodies against SARS-CoV-2 are a clinically validated therapeutic option
against COVID-19. Because rapidly emerging virus mutants are becoming the next major …
against COVID-19. Because rapidly emerging virus mutants are becoming the next major …
Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals
The COVID-19 pandemic is a major threat to global health for which there are only limited
medical countermeasures, and we lack a thorough understanding of mechanisms of …
medical countermeasures, and we lack a thorough understanding of mechanisms of …
[PDF][PDF] Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins
SARS-CoV-2 infection or vaccination produces neutralizing antibody responses that
contribute to better clinical outcomes. The receptor-binding domain (RBD) and the N …
contribute to better clinical outcomes. The receptor-binding domain (RBD) and the N …
[HTML][HTML] Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies
Understanding SARS-CoV-2 evolution and host immunity is critical to control COVID-19
pandemics. At the core is an arms-race between SARS-CoV-2 antibody and angiotensin …
pandemics. At the core is an arms-race between SARS-CoV-2 antibody and angiotensin …
[HTML][HTML] Antibody resistance of SARS-CoV-2 variants B. 1.351 and B. 1.1. 7
The COVID-19 pandemic has had widespread effects across the globe, and its causative
agent, SARS-CoV-2, continues to spread. Effective interventions need to be developed to …
agent, SARS-CoV-2, continues to spread. Effective interventions need to be developed to …
[HTML][HTML] Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies
Immediately from the outset of the COVID-19 pandemic, researchers from diverse
biomedical and biological disciplines have united to study the novel pandemic virus, SARS …
biomedical and biological disciplines have united to study the novel pandemic virus, SARS …
[PDF][PDF] Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity
Most antibodies isolated from individuals with coronavirus disease 2019 (COVID-19) are
specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However …
specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However …
[HTML][HTML] Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry
Understanding the mechanism for antibody neutralization of SARS-CoV-2 is critical for the
development of effective therapeutics and vaccines. We recently isolated a large number of …
development of effective therapeutics and vaccines. We recently isolated a large number of …
Revealing the threat of emerging SARS-CoV-2 mutations to antibody therapies
The ongoing massive vaccination and the development of effective intervention offer the
long-awaited hope to end the global rage of the COVID-19 pandemic. However, the rapidly …
long-awaited hope to end the global rage of the COVID-19 pandemic. However, the rapidly …