Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters

MS Piepenbrink, JG Park, FS Oladunni… - Cell Reports …, 2021 - cell.com
SARS-CoV-2 infection results in viral burden in the respiratory tract, enabling transmission
and leading to substantial lung pathology. The 1212C2 fully human monoclonal antibody …

Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on spike and provides antiviral protection through inhalation-based delivery in …

P Hermet, B Delache, C Herate, E Wolf, G Kivi… - PLoS …, 2023 - journals.plos.org
The COVID-19 pandemic represents a global challenge that has impacted and is expected
to continue to impact the lives and health of people across the world for the foreseeable …

A potent and protective human neutralizing antibody against SARS-CoV-2 variants

S Shan, CK Mok, S Zhang, J Lan, J Li, Z Yang… - Frontiers in …, 2021 - frontiersin.org
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to
emerge and spread around the world, antibodies and vaccines to confer broad and potent …

Nasal delivery of single-domain antibody improves symptoms of SARS-CoV-2 infection in an animal model

K Haga, R Takai-Todaka, Y Matsumura, C Song… - PLoS …, 2021 - journals.plos.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the
disease COVID-19 can lead to serious symptoms, such as severe pneumonia, in the elderly …

Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

S Halwe, A Kupke, K Vanshylla, F Liberta, H Gruell… - Viruses, 2021 - mdpi.com
Despite the recent availability of vaccines against severe acute respiratory syndrome
coronavirus type 2 (SARS-CoV-2), there is an urgent need for specific anti-SARS-CoV-2 …

Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy

C Cruz-Teran, K Tiruthani, M McSweeney, A Ma… - Advanced drug delivery …, 2021 - Elsevier
To address the COVID-19 pandemic, there has been an unprecedented global effort to
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …

[HTML][HTML] A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model

J Kreye, SM Reincke, HC Kornau, E Sánchez-Sendin… - Cell, 2020 - cell.com
The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019
(COVID-19), manifesting with respiratory symptoms and multi-organ dysfunction. Detailed …

Safety and serum distribution of anti-SARS-CoV-2 monoclonal antibody MAD0004J08 after intramuscular injection

S Lanini, S Milleri, E Andreano, S Nosari… - Nature …, 2022 - nature.com
The emerging threat represented by SARS-CoV-2 variants, demands the development of
therapies for better clinical management of COVID-19. MAD0004J08 is a potent Fc …

A potent SARS-CoV-2 neutralizing human monoclonal antibody that reduces viral burden and disease severity in Syrian hamsters

AC Fagre, J Manhard, R Adams, M Eckley… - Frontiers in …, 2020 - frontiersin.org
The emergence of COVID-19 has led to a pandemic that has caused millions of cases of
disease, variable morbidity and hundreds of thousands of deaths. Currently, only remdesivir …

In vitro evaluation of therapeutic antibodies against a SARS-CoV-2 Omicron B. 1.1. 529 isolate

F Touret, C Baronti, HS Bouzidi, X de Lamballerie - Scientific Reports, 2022 - nature.com
The emergence and rapid spread of the Omicron variant of SARS-CoV-2, which has more
than 30 substitutions in the spike glycoprotein, compromises the efficacy of currently …