Cytokines and chemokines are a rapidly expanding research field in laboratory medicine,
inflammation and allergic disease. Inflammatory diseases are generally associated with …

Asthma is a heterogeneous disorder that results in recurrent attacks of breathlessness,
coughing, and wheezing that affects millions of people worldwide. Although the precise …

Asthma is a chronic inflammatory disorder of the lower airways that results in sustained
coughing and shortness of breath. In addition to greatly affecting quality of life and posing a …

» Cytokines are families of secreted proteins that mediate immune and inflammatory
reactions at local or distant sites.» Each cytokine within a cytokine family has a unique set of …

BACKGROUND: This review will enable the readers to understand the pathogenesis of
allergic inflammation, and the role of various cells and cytokines in allergic diseases …

EVOLUTION OF CYTOKINE BIOLOGY, AND NOMENCLATURE■ and nomenclature 165•
Cytokine production by antigen-presenting cells 166• Cytotoxic immunity 168• Humoral …

Manuscripts published in the “Mechanisms of allergy and clinical immunology” section of the
Journal of Allergy and Clinical Immunology during 2012 enhanced our knowledge of the …

This review highlights some of the advances in mechanisms of allergic disease, particularly
anaphylaxis, including food allergy, drug hypersensitivity, atopic dermatitis (AD), allergic …

Besides the major players IL-4, IL-13, IL-5, and IgE as targets for biologics, other mediators
have been identified that are secreted by epithelial cells and act upstream in the cascade of …

The exposure of the airway epithelium to external stimuli such as allergens, microbes, and
air pollution triggers the release of the alarmin cytokines IL-25, IL-33 and thymic stromal …