A number of BRCA1 and BRCA2 polymorphisms have been extensively studied in order to
test their association with breast cancer risk. Subsequently, discordant results were reported …

Published data on the association between BRCA2 N372H polymorphism and breast
cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta …

Purpose: Germline mutations in either BRCA1 or BRCA2 genes are responsible for the
majority of hereditary breast and ovarian cancers. At present, over thousand distinct BRCA1 …

Genetic mutation of breast cancer 1 (BRCA1) is one of the most notable factors responsible
for a proportion of breast cancer cases. BRCA1 encodes a 1,863‑amino acid protein and …

Polymorphisms in genes involved in DNA repair, steroid hormone biosynthesis/metabolism/
signaling, folate metabolism as well as cell growth are prime candidates for possible …

It is well established that rare mutations in BRCA2 predispose to familial breast cancer, but
whether common variants at this locus contribute more modest risk to sporadic breast cancer …

Background: AC/T transition—rs4987117 (the Thr1915Met polymorphism) and an A/G
transition—rs11571653 (the Met784Val polymorphism) in the BRCA2 gene were linked to …

We aimed at determining whether any association exists between six single nucleotide
polymorphisms in breast cancer associated gene (BRCA1) and the risk of breast cancer. We …

Studies investigating the association between the BRCA1 rs799917 polymorphism and
breast cancer risk have reported controversial results. In order to derive a more precise …

The breast cancer predisposition gene, BRCA2, has a large number of genetic variants of
unknown effect. The variant rs11571833, an A> T transversion in the final exon of the gene …