Serotonin by stress interaction: a susceptibility factor for the development of depression?

C Firk, CR Markus - Journal of Psychopharmacology, 2007 - journals.sagepub.com
A genetic predisposition to depression may be a potential risk factor in the development of
depression. Although the neurobiological equivaLent of the predisposition remains unclear …

Serotonin transporter gene (5-HTTLPR) is not associated with depressive symptomatology in mood disorders

A Serretti, C Cusin, E Lattuada, D Di Bella… - Molecular …, 1999 - nature.com
Disturbances of the serotoninergic neutrotransmitter system have been implicated in the
pathogenesis of mood disorders. A functional polymorphism in the upstream regulatory …

Serotonin transporter gene polymorphism (5-HTTLPR) and anxiety reactivity in daily life: A daily process approach to gene-environment interaction

KC Gunthert, TS Conner, S Armeli… - Psychosomatic …, 2007 - journals.lww.com
Objective: To test whether individuals with at least one copy of the short (S) or long (L) G
allele of the serotonin transporter polymorphism (5-HTTLPR) exhibit greater increases in …

The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults

DG Kilpatrick, KC Koenen, KJ Ruggiero… - American Journal of …, 2007 - Am Psychiatric Assoc
Objective: Disasters are associated with increased risk of posttraumatic stress disorder
(PTSD) and major depression, but no study, to the authors' knowledge, has determined …

Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression

CM Middeldorp, EJC de Geus, AL Beem, N Lakenberg… - Behavior genetics, 2007 - Springer
We studied the association between the short/long promotor-based length polymorphism of
the serotonin transporter gene (5-HTTLPR) and neuroticism, anxiety and depression …

Social supports and serotonin transporter gene moderate depression in maltreated children

J Kaufman, BZ Yang… - Proceedings of the …, 2004 - National Acad Sciences
In this study, measures of the quality and availability of social supports were found to
moderate risk for depression associated with a history of maltreatment and the presence of …

Gene–environment interaction analysis of serotonin system markers with adolescent depression

TC Eley, K Sugden, A Corsico, AM Gregory… - Molecular …, 2004 - nature.com
We report analyses from a study of gene–environment interaction in adolescent depression.
The sample was selected from 1990 adolescents aged 10–20 years: those with depression …

Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression

MR Munafò, TG Clark, KH Roberts… - Neuropsychobiology, 2006 - karger.com
Abstract Background and Objectives: An association between a polymorphism in the
serotonin transporter gene (5HTT-LPR) and the personality trait of neuroticism has been …

The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association

SAG Willis-Owen, MG Turri, MR Munafò, PG Surtees… - Biological …, 2005 - Elsevier
BACKGROUND: A promoter-based length polymorphism (5-HTTLPR) of the human
serotonin gene (SLC6A4) has exhibited inconsistent association with emotionality …

Accurate, large-scale genotyping of 5HTTLPR and flanking single nucleotide polymorphisms in an association study of depression, anxiety, and personality measures

NR Wray, MR James, SD Gordon, T Dumenil, L Ryan… - Biological …, 2009 - Elsevier
BACKGROUND: The length polymorphism repeat in the promoter region of the serotonin
transporter gene (5HTTLPR) is one of the most studied polymorphisms for association with a …