The relationship between combat‐related posttraumatic stress disorder and the 5‐HTTLPR/rs25531 polymorphism
Z Wang, DG Baker, J Harrer, M Hamner… - Depression and …, 2011 - Wiley Online Library
Background: Empirical evidence suggests that there is a significant genetic influence in the
development of posttraumatic stress disorder (PTSD). The serotonin transporter (5‐HTT) …
development of posttraumatic stress disorder (PTSD). The serotonin transporter (5‐HTT) …
5‐HTTLPR genotype and anxiety‐related personality traits: A meta‐analysis and new data
MR Munafò, NB Freimer, W Ng, R Ophoff… - American Journal of …, 2009 - Wiley Online Library
We investigated the strength of evidence for association of the 5‐HTTLPR polymorphism
and the personality trait of Harm Avoidance. We used new primary data from a large sample …
and the personality trait of Harm Avoidance. We used new primary data from a large sample …
Brain-derived neurotrophic factor–5-HTTLPR gene interactions and environmental modifiers of depression in children
BACKGROUND: Child abuse and genotype interact to contribute to risk for depression in
children. This study examined gene-by-gene and gene-by-environment interactions …
children. This study examined gene-by-gene and gene-by-environment interactions …
Stressful life events, 5-HTT genotype and risk of depression
S Zammit, MJ Owen - The British Journal of Psychiatry, 2006 - cambridge.org
Studies of how genetic and environmental exposures interact may be essential for
understanding the aetiology of complex psychiatric disorders. In this issue of the Journal an …
understanding the aetiology of complex psychiatric disorders. In this issue of the Journal an …
Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders
BACKGROUND: It has been reported that the functional polymorphism in the serotonin
transporter gene linked promoter region (5-HTTLPR) modifies the association between …
transporter gene linked promoter region (5-HTTLPR) modifies the association between …
Influence of life stress, 5-HTTLPR genotype, and SLC6A4 methylation on gene expression and stress response in healthy Caucasian males
EA Duman, T Canli - Biology of mood & anxiety disorders, 2015 - Springer
Background Previous research reported that individual differences in the stress response
were moderated by an interaction between individuals' life stress experience and the …
were moderated by an interaction between individuals' life stress experience and the …
Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder
M Kato, A Serretti - Molecular psychiatry, 2010 - nature.com
This systematic review summarizes pharmacogenetic studies on antidepressant response
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta …
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta …
A susceptibility gene for affective disorders and the response of the human amygdala
AR Hariri, EM Drabant, KE Munoz… - Archives of general …, 2005 - jamanetwork.com
Background A common regulatory variant (5-HTTLPR) in the human serotonin transporter
gene (SLC6A4), resulting in altered transcription and transporter availability, has been …
gene (SLC6A4), resulting in altered transcription and transporter availability, has been …
Early adversity and 5-HTT/BDNF genes: new evidence of gene–environment interactions on depressive symptoms in a general population
BackgroundAdverse childhood experiences have been described as one of the major
environmental risk factors for depressive disorder. Similarly, the deleterious impact of early …
environmental risk factors for depressive disorder. Similarly, the deleterious impact of early …