The pharmacological attenuation of glial activation represents a novel approach for
controlling neuropathic pain, but the role of microglial and astroglial cells is not well …

Mounting evidence supports the hypothesis that spinal microglia modulate the development
and maintenance of some chronic pain states. Here we examined the role of spinal …

Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating
enhanced pain states by releasing proinflammatory cytokines and other substances thought …

Development of next-generation analgesics requires a better understanding of the
molecular and cellular mechanisms underlying pathological pain. Accumulating evidence …

Peripheral nerve injuries that provoke neuropathic pain are associated with microglial
activation in the spinal cord. We have investigated the characteristics of spinal microglial …

Background: Clinical studies of osteoarthritis (OA) suggest central sensitization may
contribute to the chronic pain experienced. This preclinical study used the monosodium …

Activation of spinal cord microglia and astrocytes is a common phenomenon in nerve injury
pain models and is thought to exacerbate pain perception. Following a nerve injury, a …

Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic
central pain, which can be refractory to conventional treatment approaches. It has been …

Peripheral nerve injury commonly leads to neuropathic pain states fostered, in part, by
neuroimmunologic events. We used two models of neuropathic pain (L5 spinal nerve …

Neuronal plasticity along the pathway for sensory transmission including the spinal cord and
cortex plays an important role in chronic pain, including inflammatory and neuropathic pain …