The Nonstructural Protein NSs of Severe Fever with Thrombocytopenia Syndrome Virus Causes a Cytokine Storm through the Hyperactivation of NF-κB

J Khalil, S Yamada, Y Tsukamoto, H Abe… - … and Cellular Biology, 2021 - Taylor & Francis
Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging highly
pathogenic phlebovirus. The syndrome is characterized by the substantial production of …

Suppression of the interferon and NF-κB responses by severe fever with thrombocytopenia syndrome virus

B Qu, X Qi, X Wu, M Liang, C Li, CJ Cardona… - Journal of …, 2012 - Am Soc Microbiol
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease
characterized by high fever, thrombocytopenia, multiorgan dysfunction, and a high fatality …

The NSs protein of severe fever with thrombocytopenia syndrome virus differentially inhibits the type 1 interferon response among animal species

R Yoshikawa, M Kawakami, J Yasuda - Journal of Biological Chemistry, 2023 - ASBMB
Severe fever with thrombocytopenia syndrome virus (SFTSV), which has been reported in
China, Korea, Japan, Vietnam, and Taiwan, is a causative agent of severe fever …

Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and …

V Chaudhary, S Zhang, KS Yuen… - Journal of General …, 2015 - microbiologyresearch.org
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne
pathogen causing significant morbidity and mortality in Asia. NSs protein of SFTSV is known …

[HTML][HTML] Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus inhibits TBK1 to evade interferon-mediated response

JK Lee, OS Shin - Journal of microbiology and biotechnology, 2021 - ncbi.nlm.nih.gov
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging phlebovirus of
the Phenuiviridae family that has been circulating in the following Asian countries: Vietnam …

Two conserved amino acids within the NSs of severe fever with thrombocytopenia syndrome phlebovirus are essential for anti-interferon activity

M Moriyama, M Igarashi, T Koshiba, T Irie… - Journal of …, 2018 - Am Soc Microbiol
The nonstructural protein (NSs) of severe fever with thrombocytopenia syndrome
phlebovirus (SFTSV) sequesters TANK-binding kinase 1 (TBK1) into NSs-induced …

NSs protein of severe fever with thrombocytopenia syndrome virus suppresses interferon production through different mechanism than Rift Valley fever virus.

S Zhang, B Zheng, T Wang, A Li, J Wan, J Qu, CH Li… - Acta virologica, 2017 - europepmc.org
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a newly identified
Phlebovirus that causes severe fever with thrombocytopenia syndrome. Our study …

The role of non-structural protein NSs in the pathogenesis of severe fever with thrombocytopenia syndrome

J Khalil, H Kato, T Fujita - Viruses, 2021 - mdpi.com
Viral non-structural proteins, such as NSs of the newly emerging severe fever with
thrombocytopenia syndrome virus, are well established virulence factors, mediating viral …

Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis

Y Choi, SJ Park, Y Sun, JS Yoo, RS Pudupakam… - Nature …, 2019 - nature.com
Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV), listed in the World
Health Organization Prioritized Pathogens, is an emerging phlebovirus with a high fatality …

Roles of viroplasm‐like structures formed by nonstructural protein NSs in infection with severe fever with thrombocytopenia syndrome virus

X Wu, X Qi, M Liang, C Li, CJ Cardona, D Li… - The FASEB …, 2014 - Wiley Online Library
Severe fever with thrombocytopenia syndrome (SFTS) virus is an emerging bunyavirus that
causes a hemorrhagic fever with a high mortality rate. The virus is likely tick‐borne and …