Human aging alters the neural computation and representation of space
The hippocampus and striatum are core neural circuits involved in spatial learning and
memory. Although both neural systems support spatial navigation, experimental and …
memory. Although both neural systems support spatial navigation, experimental and …
[HTML][HTML] Volume of the posterior hippocampus mediates age-related differences in spatial context memory and is correlated with increased activity in lateral frontal …
Healthy aging is associated with episodic memory decline, particularly in the ability to
encode and retrieve object-context associations (context memory). Neuropsychological and …
encode and retrieve object-context associations (context memory). Neuropsychological and …
What do we know about aging and spatial cognition? Reviews and perspectives
G Klencklen, O Després, A Dufour - Ageing research reviews, 2012 - Elsevier
In order to cope with normal cognitive aging we must understand the patterns and
neurofunctional underpinnings of cognitive and behavioral changes throughout adulthood …
neurofunctional underpinnings of cognitive and behavioral changes throughout adulthood …
Spatial memory—a unique window into healthy and pathological aging
The world's population is aging at an unprecedented rate, because the number of people
aged over 60 will rise from 784 million in 2011 to 2 billion by 2050. Such a dramatic increase …
aged over 60 will rise from 784 million in 2011 to 2 billion by 2050. Such a dramatic increase …
Spatial updating deficits in human aging are associated with traces of former memory representations
The ability to update spatial memories is important for everyday situations, such as
remembering where we left our keys or parked our car. Although rodent studies have …
remembering where we left our keys or parked our car. Although rodent studies have …
Hippocampal contributions to novel spatial learning are both age-related and age-invariant
Older adults show declines in spatial memory, although the extent of these alterations is not
uniform across the healthy older population. Here, we investigate the stability of neural …
uniform across the healthy older population. Here, we investigate the stability of neural …
Extrahippocampal contributions to age differences in human spatial navigation
The hippocampus (HC) and associated neural structures are hypothesized to contribute to
individual differences in human spatial navigation. However, functional imaging studies and …
individual differences in human spatial navigation. However, functional imaging studies and …
Increased hippocampal excitability and altered learning dynamics mediate cognitive mapping deficits in human aging
N Diersch, JP Valdes-Herrera… - Journal of …, 2021 - Soc Neuroscience
Learning the spatial layout of a novel environment is associated with dynamic activity
changes in the hippocampus and in medial parietal areas. With advancing age, the ability to …
changes in the hippocampus and in medial parietal areas. With advancing age, the ability to …
Age-associated changes in the hippocampal-ventral striatum-ventral tegmental loop that impact learning, prediction, and context discrimination
MR Penner, SJY Mizumori - Frontiers in aging neuroscience, 2012 - frontiersin.org
Studies of the neural mechanisms of navigation and context discrimination have generated
a powerful heuristic for understanding how neural codes, circuits, and computations …
a powerful heuristic for understanding how neural codes, circuits, and computations …
[HTML][HTML] Spatial navigational strategies correlate with gray matter in the hippocampus of healthy older adults tested in a virtual maze
K Konishi, VD Bohbot - Frontiers in aging neuroscience, 2013 - frontiersin.org
Healthy young adults use different strategies when navigating in a virtual maze. Spatial
strategies involve using environmental landmarks while response strategies involve …
strategies involve using environmental landmarks while response strategies involve …