A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors
Targeted nanoparticles are increasingly being engineered for the treatment of cancer. By
design, they can passively accumulate in tumors, selectively bind to targets in their …
design, they can passively accumulate in tumors, selectively bind to targets in their …
Tailoring nanoparticle designs to target cancer based on tumor pathophysiology
Nanoparticles can provide significant improvements in the diagnosis and treatment of
cancer. How nanoparticle size, shape, and surface chemistry can affect their accumulation …
cancer. How nanoparticle size, shape, and surface chemistry can affect their accumulation …
An experimental and computational framework for engineering multifunctional nanoparticles: designing selective anticancer therapies
A key challenge in the treatment of cancer with nanomedicine is to engineer and select
nanoparticle formulations that lead to the desired selectivity between tumorigenic and non …
nanoparticle formulations that lead to the desired selectivity between tumorigenic and non …
Principles of nanoparticle delivery to solid tumors
WCW Chan - BME frontiers, 2023 - spj.science.org
The effective treatment of patients with cancer hinges on the delivery of therapeutics to a
tumor site. Nanoparticles provide an essential transport system. We present 5 principles to …
tumor site. Nanoparticles provide an essential transport system. We present 5 principles to …
Multi-objective optimization of tumor response to drug release from vasculature-bound nanoparticles
The pharmacokinetics of nanoparticle-borne drugs targeting tumors depends critically on
nanoparticle design. Empirical approaches to evaluate such designs in order to maximize …
nanoparticle design. Empirical approaches to evaluate such designs in order to maximize …
Computational design of nanoparticle drug delivery systems for selective targeting
Ligand-functionalized nanoparticles capable of selectively binding to diseased versus
healthy cell populations are attractive for improved efficacy of nanoparticle-based drug and …
healthy cell populations are attractive for improved efficacy of nanoparticle-based drug and …
In silico modelling of cancer nanomedicine, across scales and transport barriers
Nanoparticles promise to improve the treatment of cancer through their increasingly
sophisticated functionalisations and ability to accumulate in certain tumours. Yet recent work …
sophisticated functionalisations and ability to accumulate in certain tumours. Yet recent work …
Design of nanoparticle‐based carriers for targeted drug delivery
Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor
systems, but they must be properly designed in order to maximize efficacy. Computational …
systems, but they must be properly designed in order to maximize efficacy. Computational …
[HTML][HTML] Understanding the connection between nanoparticle uptake and cancer treatment efficacy using mathematical modeling
Nanoparticles have shown great promise in improving cancer treatment efficacy while
reducing toxicity and treatment side effects. Predicting the treatment outcome for …
reducing toxicity and treatment side effects. Predicting the treatment outcome for …
Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunities
CL Waite, CM Roth - Critical Reviews™ in Biomedical …, 2012 - dl.begellhouse.com
Poor penetration of anticancer drags into solid tumors significantly limits their efficacy. This
phenomenon has long been observed for small-molecule chemotherapeutics, and it can be …
phenomenon has long been observed for small-molecule chemotherapeutics, and it can be …