S Cianfarani - Frontiers in Endocrinology, 2021 - frontiersin.org
Growth hormone (GH) therapy dates back to 1958 and, though has shown an excellent safety profile in the short-term, has never ceased to raise concern about potential long-term …
D Dunger, F Darendeliler, N Kandemir… - Journal of Pediatric …, 2020 - degruyter.com
Background An increasing body of evidence supports the view that both an adverse intrauterine milieu and rapid postnatal weight gain in children born small for gestational age …
WJ Goedegebuure, M van der Steen… - The Lancet Child & …, 2022 - thelancet.com
Background Childhood growth hormone treatment has been associated with increased cardiovascular mortality and morbidity in adults born small for gestational age (SGA) …
A Berglund, CH Gravholt, MS Olsen… - Clinical …, 2015 - Wiley Online Library
Context Long‐term safety of growth hormone (GH) treatment is an area of much debate. Studies including children treated with GH not only due to GHD, but also due to non‐GHD …
L Sävendahl, M Polak, P Backeljauw… - The Journal of …, 2021 - academic.oup.com
Context Growth hormone (GH) treatment has a generally good safety profile; however, concerns about increased mortality risk in adulthood have been raised. Objective This work …
V Bamba, R Kanakatti Shankar - The Journal of Clinical …, 2022 - academic.oup.com
The use of recombinant human growth hormone (rhGH) in children and adolescents has expanded since its initial approval to treat patients with severe GH deficiency (GHD) in 1985 …
K Stochholm, W Kiess - Clinical endocrinology, 2018 - Wiley Online Library
Objectives Preliminary data from the French cohort of the Safety and Appropriateness of Growth hormone treatments in Europe (SAG hE) study raised concerns regarding the safety …
M van der Steen, AJ Lem… - The Journal of …, 2015 - academic.oup.com
Context: Previously we showed that pubertal children born small for gestational age (SGA) with a poor adult height (AH) expectation can benefit from treatment with GH 1 mg/m2 per …
J Bell, KL Parker, RD Swinford… - The Journal of …, 2010 - academic.oup.com
Abstract Background: Between 1985 and 2006, the National Cooperative Growth Study (NCGS) monitored the safety and efficacy of recombinant human growth hormone (rhGH) in …