Background: In attempting to understand the familial basis of depression, most studies have
focused on broad indices of depression and mood change. Broad indices may not …

To identify the genomic regions that confer risk and protection for major depressive disorder
(MDD) in humans, large-scale studies are needed. Such studies should collect multiple …

The recent successful genome-wide association studies (GWASs) for depression have
yielded more than 80 replicated loci and brought back the excitement that had evaporated …

There is heterogeneity between depression in childhood, adolescence and adulthood in
terms of the gender composition of affected cases, prevalence, rates of recurrence and risk …

Major depression is a common disorder, accounting for more disability than any other
disorder worldwide. The rates of major depression in the United States rose markedly in the …

OBJECTIVE: The authors conducted a meta-analysis of relevant data from primary studies of
the genetic epidemiology of major depression. METHOD: The authors searched MEDLINE …

The recent success of a large genome-wide association (GWA) study—analysing 130 620
major depression cases and 347 620 controls—in identifying the first single-nucleotide …

Objective: The authors carried out a genomewide linkage scan to identify chromosomal
regions likely to contain genes that contribute to susceptibility to recurrent early-onset major …

Despite strong evidence supporting the heritability of major depressive disorder (MDD),
previous genome-wide studies were unable to identify risk loci among individuals of …

BACKGROUND: Depression is a heritable trait that exists on a continuum of varying severity
and duration. Yet, the search for genetic variants associated with depression has had few …