Identification of 15 genetic loci associated with risk of major depression in individuals of European descent
Despite strong evidence supporting the heritability of major depressive disorder (MDD),
previous genome-wide studies were unable to identify risk loci among individuals of …
previous genome-wide studies were unable to identify risk loci among individuals of …
Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes?
KS Kendler, CO Gardner, MC Neale… - Psychological …, 2001 - cambridge.org
Background. Although women are at consistently greater risk for major depression (MD)
than men, it is unclear whether sex modifies the aetiological impact of genetic factors on MD …
than men, it is unclear whether sex modifies the aetiological impact of genetic factors on MD …
Polygenic risk: predicting depression outcomes in clinical and epidemiological cohorts of youths
T Halldorsdottir, C Piechaczek… - American Journal of …, 2019 - Am Psychiatric Assoc
Objective: Identifying risk factors for major depression and depressive symptoms in youths
could have important implications for prevention efforts. This study examined the association …
could have important implications for prevention efforts. This study examined the association …
Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
Meta-analyses of genetic studies on major depressive disorder
S López-León, A Janssens… - Molecular …, 2008 - nature.com
The genetic basis of major depressive disorder (MDD) has been investigated extensively,
but the identification of MDD genes has been hampered by conflicting results from …
but the identification of MDD genes has been hampered by conflicting results from …
Gene-environment interactions: biologically valid pathway or artifact?
M Rutter, A Thapar, A Pickles - Archives of general psychiatry, 2009 - jamanetwork.com
JAMA Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life
Events, and Risk of Depression: A Meta-analysis Neil Risch, PhD; Richard Herrell, PhD; …
Events, and Risk of Depression: A Meta-analysis Neil Risch, PhD; Richard Herrell, PhD; …
The genetic and environmental relationship between major depression and the five-factor model of personality
KS Kendler, J Myers - Psychological medicine, 2010 - cambridge.org
BackgroundCertain personality traits have long been suspected to reflect an enduring
vulnerability to major depression (MD) in part because of shared genetic risk factors …
vulnerability to major depression (MD) in part because of shared genetic risk factors …
Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned
NR Wray, ML Pergadia, DHR Blackwood… - Molecular …, 2012 - nature.com
Major depressive disorder (MDD) is a common complex disorder with a partly genetic
etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 …
etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 …
Molecular genetic analysis subdivided by adversity exposure suggests etiologic heterogeneity in major depression
Objective: The extent to which major depression is the outcome of a single biological
mechanism or represents a final common pathway of multiple disease processes remains …
mechanism or represents a final common pathway of multiple disease processes remains …
High dimensional endophenotype ranking in the search for major depression risk genes
BACKGROUND: Despite overwhelming evidence that major depression is highly heritable,
recent studies have localized only a single depression-related locus reaching genome-wide …
recent studies have localized only a single depression-related locus reaching genome-wide …