Background Antibiotic resistance represents a significant public health problem. When
resistance genes are mobile, being carried on plasmids or phages, their spread can be …

Many antibiotic resistance genes are associated with plasmids. The ecological success of
these mobile genetic elements within microbial communities depends on varying …

The global dissemination of plasmids encoding antibiotic resistance represents an urgent
issue for human health and society. While the fitness costs for host cells associated with …

Abstract The World Health Organization has declared the emergence of antibiotic resistance
to be a global threat to human health. Broad-host-range plasmids have a key role in causing …

Antibiotic resistance encoded on plasmids is a pressing global health problem. Predicting
which plasmids spread in the long term remains very challenging, even though some key …

Naturally occurring plasmids have medical importance given that they frequently code for
virulence or antibiotic resistance. In many cases, plasmids impose a fitness cost to their …

With plasmid-mediated antibiotic resistance thriving and threatening to become a serious
public health problem, it is paramount to increase our understanding of the forces that …

The emergence and spread of antibiotic resistance among human pathogens is a relevant
problem for human health and one of the few evolution processes amenable to experimental …

The evolutionary pressures that determine the location (chromosomal or plasmid-borne) of
bacterial genes are not fully understood. We investigate these pressures through …

The evolution of antibiotic resistance carries a fitness cost, expressed in terms of reduced
competitive ability in the absence of antibiotics. This cost plays a key role in the dynamics of …