Numerical comparison of nasal aerosol administration systems for efficient nose-to-brain drug delivery
Purpose Nose-to-brain drug administration along the olfactory and trigeminal nerve
pathways offers an alternative route for the treatment of central nervous system (CNS) …
pathways offers an alternative route for the treatment of central nervous system (CNS) …
First steps to develop and validate a CFPD model in order to support the design of nose-to-brain delivered biopharmaceuticals
L Engelhardt, M Röhm, C Mavoungou… - Pharmaceutical …, 2016 - Springer
Purpose Aerosol particle deposition in the human nasal cavity is of high interest in particular
for intranasal central nervous system (CNS) drug delivery via the olfactory cleft. The …
for intranasal central nervous system (CNS) drug delivery via the olfactory cleft. The …
Pulsatile bi-directional aerosol flow affects aerosol delivery to the intranasal olfactory region: a patient-specific computational study
A Farnoud, H Tofighian, I Baumann… - Frontiers in …, 2021 - frontiersin.org
The nasal olfactory region is a potential route for non-invasive delivery of drugs directly from
the nasal epithelium to the brain, bypassing the often impermeable blood-brain barrier …
the nasal epithelium to the brain, bypassing the often impermeable blood-brain barrier …
Olfactory targeting of microparticles through inhalation and bi-directional airflow: effect of particle size and nasal anatomy
Background: Targeting drugs to the olfactory region in the nasal cavity can bypass the
restrictive blood–brain barrier and enhance their direct delivery to the brain. However …
restrictive blood–brain barrier and enhance their direct delivery to the brain. However …
Numerical and machine learning analysis of the parameters affecting the regionally delivered nasal dose of nano-and micro-sized aerosolized drugs
The nasal epithelium is an important target for drug delivery to the nose and secondary
organs such as the brain via the olfactory bulb. For both topical and brain delivery, the …
organs such as the brain via the olfactory bulb. For both topical and brain delivery, the …
Nasal and Olfactory Deposition with Normal and Bidirectional Intranasal Delivery Techniques: In Vitro Tests and Numerical Simulations
J Xi, Z Wang, D Nevorski, T White… - Journal of Aerosol …, 2017 - liebertpub.com
Background: Intranasal delivery protocols that can effectively deposit drugs to the olfactory
region are severely lacking. Furthermore, it is still challenging to quantify nasal deposition …
region are severely lacking. Furthermore, it is still challenging to quantify nasal deposition …
Regional deposition of nasal sprays in adults: A wide ranging computational study
M Kiaee, H Wachtel, ML Noga… - International Journal …, 2018 - Wiley Online Library
The present work examines regional deposition within the nose for nasal sprays over a large
and wide ranging parameter space by using numerical simulation. A set of 7 realistic adult …
and wide ranging parameter space by using numerical simulation. A set of 7 realistic adult …
In vitro evaluation of nasal aerosol depositions: an insight for direct nose to brain drug delivery
A Maaz, IS Blagbrough, PA De Bank - Pharmaceutics, 2021 - mdpi.com
The nasal cavity is an attractive route for both local and systemic drug delivery and holds
great potential for access to the brain via the olfactory region, an area where the blood–brain …
great potential for access to the brain via the olfactory region, an area where the blood–brain …
Design and testing of electric-guided delivery of charged particles to the olfactory region: Experimental and numerical studies
J Xi, J Eddie Yuan, M Alshaiba, D Cheng… - Current Drug …, 2016 - ingentaconnect.com
Neurological drugs delivered to the olfactory region can enter the brain via olfactory
pathways and bypass the blood-brain barrier. However, clinical applications of the direct …
pathways and bypass the blood-brain barrier. However, clinical applications of the direct …
Comparison of micron-and nano-particle transport in the human nasal cavity with a focus on the olfactory region
S Vachhani, C Kleinstreuer - Computers in Biology and Medicine, 2021 - Elsevier
Intranasal administration of drugs serves as a promising, noninvasive option for the
treatment of various disorders of the central nervous system and upper respiratory tract …
treatment of various disorders of the central nervous system and upper respiratory tract …