The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …

SARS-CoV-2 or COVID-19 has caused more than 10, 00,000 infections and~ 55,000 deaths
worldwide spanning over 203 countries, and the numbers are exponentially increasing. Due …

The current ongoing pandemic of COVID-19 urges immediate treatment measures for
controlling the highly contagious SARS-CoV-2 infections. The papain-like protease (PLpro) …

The emergence of SARS-CoV-2 variants and drug-resistant mutants calls for additional oral
antivirals. The SARS-CoV-2 papain-like protease (PLpro) is a promising but challenging …

Inhibition of the papain-like protease (PLpro) of SARS-CoV-2 has been demonstrated to be
a successful target to prevent the spreading of the coronavirus in the infected body. In this …

Coronavirus disease 2019 (COVID-19) pandemic, a global health threat, was caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 papain …

Structure-guided design was used to generate a series of noncovalent inhibitors with
nanomolar potency against the papain-like protease (PLpro) from the SARS coronavirus …

The global COVID-19 pandemic underscores the dire need for effective antivirals.
Encouraging progress has been made in developing small-molecule inhibitors targeting the …

The COVID-19 pandemic caused by SARS-CoV-2 has emerged as a global catastrophe.
The virus requires main protease for processing the viral polyproteins PP1A and PP1AB …

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), continues to be a global threat since its emergence. Although …