Our current understanding of the vascular biology of atherogenesis and its clinical
manifestations suggests a pathophysiology that is much more complex than mere lipid …

Complex cellular and inflammatory interactions are involved in the progress of vascular
diseases. Endothelial cells, upon exposure to cytokines, undergo profound alterations of …

Angiotensin II (ANG II) promotes vascular inflammation through nuclear factor-κB (NF-κB)-
mediated induction of pro-inflammatory genes. The role of peroxisome proliferator-activated …

Inhibition of the actions of angiotensin II serves a dual purpose: indirectly through reduction
of mechanical stress on the vascular wall, and directly by diminished stimulation for vascular …

The pro-oxidative and pro-inflammatory pathways in vascular endothelium have been
implicated in the initiation and progression of atherosclerosis. In fact, inflammatory …

Atherosclerosis, the cause of myocardial infarction, stroke, and ischemic gangrene, is an
inflammatory disease. The atherosclerotic process is initiated when cholesterol-containing …

Clinical and experimental data support a link between endothelial dysfunction and
inflammation. Inflammatory cytokines are important protagonists in formation of …

Angiotensin II (Ang II) is associated with vascular hypertrophy, endothelial dysfunction and
activation of a number of inflammatory molecules, however the linear events involved in the …

Abstract Rudolph Virchow (1821–1902) recognized inflammation in histological
preparations of coronary arteries and proposed that inflammation plays a causal role in …

Many molecular and cellular mechanisms link inflammation and haemostatic mechanisms.
Inflammation, and perhaps chronic infection, may play important roles in the initiation and …