Background Standard laboratory techniques, such as viral culture and serology, provide
only circumstantial or retrospective evidence of viral infections of the central nervous system …

The cerebrospinal fluid (CSF) polymerase chain reaction (PCR) is the gold standard to
detect cerebral viral activity. As positive findings do not prove an impact on the neurological …

Background. Polymerase chain reaction (PCR) is becoming more common in diagnostic
laboratories. In some instances, its value has been established. In other cases, assays exist …

Background: Polymerase chain reaction (PCR) is used to detect viruses in the cerebrospinal
fluid (CSF) of patients with neurological disease. However, data to assist its use or …

Multiple sclerosis (MS) is a serious chronic neurological disorder in which demyelination
and inflammation occur in the white matter of the CNS. The findings of many epidemiological …

The etiology of encephalitis and meningitis, serious diseases of the central nervous system
(CNS), in most cases remains unknown. The importance of establishing a diagnosis …

Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably
improved the diagnosis of several acute, subacute and chronic viral infections of the nervous …

ABSTRACT A multiplex PCR assay that detects the four commonest causes of viral
meningitis and encephalitis in the United Kingdom (herpes simplex virus [HSV] type 1 [HSV …

In this study we have devised a simple and robust PCR strategy to detect a wide range of
viruses, bacteria, and parasites, all of which are capable of causing aseptic meningitis and …

Background: Infections of the central nervous system (CNS) are a difficult diagnostic
problem for both clinicians and microbiologists. Various clinical signs, such as encephalitis …