As the field of genetics research advances, our understanding of complex diseases and their
underlying mechanisms has expanded exponentially. Genomewide association studies …

Rheumatic diseases have many overlapping clinical features, which can complicate the
differentiation between shared and unique underlying immunopathological mechanisms …

Early identification of genetically validated drug targets can increase the chances of
successful late-stage drug development. 81 high-quality genome-wide association studies …

As comprehensive electronic medical records increas ingly capture more data points from
large-scale clini cal cohorts, machine-learning approaches have been applied to identify …

Background Genetic factors have a substantial role in determining development of
rheumatoid arthritis (RA), and are likely to account for 50–60% of disease susceptibility …

Robert Kirsner and colleagues (Sept 15, p 977) 1 describe a spray formulation of allogeneic
neonatal keratinocytes and fibroblasts for the treatment of chronic venous leg ulcers. Such …

The two major goals of common disease genetics research have been dissection of the
aetiopathogenesis of common diseases, and the development of genetic predictors or …

Osteoarthritis is a leading cause of disability and important cause of increasing health
burden among older populations. To date, most population-based epidemiological …

One of the most widely used and potentially revolutionary biomedical research tools derived
from the human genome project has been the DNA microarray (or geneexpression array). A …

Comment www. thelancet. com/rheumatology Vol 3 January 2021 e7 before the onset of
clinical symptoms; and the presence of human leukocyte anti gen (HLA)-DR alleles that …