[HTML][HTML] A genome-wide association study suggests novel loci associated with a schizophrenia-related brain-based phenotype
Patients with schizophrenia and their siblings typically show subtle changes of brain
structures, such as a reduction of hippocampal volume. Hippocampal volume is heritable …
structures, such as a reduction of hippocampal volume. Hippocampal volume is heritable …
Genetic overlap between schizophrenia and volumes of hippocampus, putamen, and intracranial volume indicates shared molecular genetic mechanisms
Schizophrenia (SCZ) is associated with differences in subcortical brain volumes and
intracranial volume (ICV). However, little is known about the underlying etiology of these …
intracranial volume (ICV). However, little is known about the underlying etiology of these …
A transcriptome-wide association study implicates specific pre-and post-synaptic abnormalities in schizophrenia
Schizophrenia is a complex highly heritable disorder. Genome-wide association studies
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …
(GWAS) have identified multiple loci that influence the risk of developing schizophrenia …
[HTML][HTML] A role for noncoding variation in schizophrenia
A large portion of common variant loci associated with genetic risk for schizophrenia reside
within noncoding sequence of unknown function. Here, we demonstrate promoter and …
within noncoding sequence of unknown function. Here, we demonstrate promoter and …
Genetic schizophrenia risk variants jointly modulate total brain and white matter volume
AFT Van Scheltinga, SC Bakker, NEM Van Haren… - Biological …, 2013 - Elsevier
BACKGROUND: Thousands of common single nucleotide polymorphisms (SNPs) are
weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs …
weakly associated with schizophrenia. It is likely that subsets of disease-associated SNPs …
Genomic insights into schizophrenia
MJ Owen - Royal Society Open Science, 2023 - royalsocietypublishing.org
Schizophrenia is a common, complex, heterogeneous psychiatric syndrome which can have
profound impacts on affected individuals and imposes significant burdens on society …
profound impacts on affected individuals and imposes significant burdens on society …
Polygenic effects of schizophrenia on hippocampal grey matter volume and hippocampus–medial prefrontal cortex functional connectivity
BackgroundSchizophrenia is a complex mental disorder with high heritability and polygenic
inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of …
inheritance. Multimodal neuroimaging studies have also indicated that abnormalities of …
[HTML][HTML] Impact of polygenic schizophrenia-related risk and hippocampal volumes on the onset of psychosis
F Harrisberger, R Smieskova, C Vogler, T Egli… - Translational …, 2016 - nature.com
Alterations in hippocampal volume are a known marker for first-episode psychosis (FEP) as
well as for the clinical high-risk state. The Polygenic Schizophrenia-related Risk Score …
well as for the clinical high-risk state. The Polygenic Schizophrenia-related Risk Score …
Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia
Schizophrenia is a devastating neurodevelopmental disorder with a complex genetic
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
etiology. Widespread cortical gray matter loss has been observed in patients and prodromal …
Genetic insights into the neurodevelopmental origins of schizophrenia
R Birnbaum, DR Weinberger - Nature Reviews Neuroscience, 2017 - nature.com
Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …
neurobiological investigation. Although the underlying causal mechanisms remain …