Spirocyclopropane represents a privileged structural scaffold for accessing synthetic
libraries of densely functionalized spirocarbo-and heterocyclic compounds. Due to the …

Spirocyclic compounds fascinate the synthetic chemists due to their privileged ring system
and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their …

The construction of heterocyclic compounds from activated cyclopropane derivatives offers
an alternative strategy for the preparation of molecules that may be of interest from a …

Spirocycles frequently occur in natural products and experience increasing interest in drug
discovery, given their richness in sp3 centers and distinct three‐dimensionality. We have …

The cyclopentane carbocyclic ring system, while ubiquitous in nature, is not usually
considered a privileged core structure for the development of a drug candidate due, in part …

A novel double cascade synthetic strategy was developed for the diastereoselective
syntheses of cis-fused bicyclic ethers, featuring cascade Achmatowicz rearrangement …

A systematic stereocontrolled synthesis of benzannulated spiroketals has been developed,
using kinetic spirocyclization reactions of glycal epoxides, leading to a new AcOH-induced …

In recent years the pharmaceutical industry has benefited from the advances made in
fragment‐based drug discovery (FBDD) with more than 30 fragment‐derived drugs currently …

Covering: up to the end of 2010 Polycyclic structures fused at a central carbon are of great
interest due to their appealing conformational features and their structural implications in …

The last two decades or so have witnessed an upsurge in defining the art of designing
complex natural products and nature-inspired molecules. Throughout these decades …